Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>
A known polyoxygenated briarane, briaexcavatolide P (<b>1</b>), was isolated from a Formosan octocoral <i>Briareum stechei</i>. Moreover, the same species <i>B. stechei</i>, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two...
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| Autores principales: | , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/61b6a9b4de5c47f8ad4d9976248c1853 |
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| Sumario: | A known polyoxygenated briarane, briaexcavatolide P (<b>1</b>), was isolated from a Formosan octocoral <i>Briareum stechei</i>. Moreover, the same species <i>B. stechei</i>, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (<b>2</b>) and C (<b>3</b>) as well as a known analogue, briarenol R (<b>4</b>). The structures of <b>1</b>–<b>4</b> were established using spectroscopic methods. In addition, briarane <b>1</b> demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein. |
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