Briarane-Related Diterpenoids from Octocoral Briareum stechei

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two...

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Autores principales:	Thanh-Hao Huynh, Choo-Aun Neoh, Yu-Chi Tsai, Zhi-Kang Yao, Li-Guo Zheng, Pin-Chang Huang, Zhi-Hong Wen, Jih-Jung Chen, Yu-Jen Wu, Ping-Jyun Sung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Briareum stechei</i> briarane briaexcavatolie briastecholide iNOS Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/61b6a9b4de5c47f8ad4d9976248c1853
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spelling	oai:doaj.org-article:61b6a9b4de5c47f8ad4d9976248c18532021-11-25T18:27:54ZBriarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>10.3390/molecules262268611420-3049https://doaj.org/article/61b6a9b4de5c47f8ad4d9976248c18532021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6861https://doaj.org/toc/1420-3049A known polyoxygenated briarane, briaexcavatolide P (<b>1</b>), was isolated from a Formosan octocoral <i>Briareum stechei</i>. Moreover, the same species <i>B. stechei</i>, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (<b>2</b>) and C (<b>3</b>) as well as a known analogue, briarenol R (<b>4</b>). The structures of <b>1</b>–<b>4</b> were established using spectroscopic methods. In addition, briarane <b>1</b> demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.Thanh-Hao HuynhChoo-Aun NeohYu-Chi TsaiZhi-Kang YaoLi-Guo ZhengPin-Chang HuangZhi-Hong WenJih-Jung ChenYu-Jen WuPing-Jyun SungMDPI AGarticle<i>Briareum stechei</i>briaranebriaexcavatoliebriastecholideiNOSOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6861, p 6861 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Briareum stechei</i> briarane briaexcavatolie briastecholide iNOS Organic chemistry QD241-441
spellingShingle	<i>Briareum stechei</i> briarane briaexcavatolie briastecholide iNOS Organic chemistry QD241-441 Thanh-Hao Huynh Choo-Aun Neoh Yu-Chi Tsai Zhi-Kang Yao Li-Guo Zheng Pin-Chang Huang Zhi-Hong Wen Jih-Jung Chen Yu-Jen Wu Ping-Jyun Sung Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>
description	A known polyoxygenated briarane, briaexcavatolide P (<b>1</b>), was isolated from a Formosan octocoral <i>Briareum stechei</i>. Moreover, the same species <i>B. stechei</i>, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (<b>2</b>) and C (<b>3</b>) as well as a known analogue, briarenol R (<b>4</b>). The structures of <b>1</b>–<b>4</b> were established using spectroscopic methods. In addition, briarane <b>1</b> demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.
format	article
author	Thanh-Hao Huynh Choo-Aun Neoh Yu-Chi Tsai Zhi-Kang Yao Li-Guo Zheng Pin-Chang Huang Zhi-Hong Wen Jih-Jung Chen Yu-Jen Wu Ping-Jyun Sung
author_facet	Thanh-Hao Huynh Choo-Aun Neoh Yu-Chi Tsai Zhi-Kang Yao Li-Guo Zheng Pin-Chang Huang Zhi-Hong Wen Jih-Jung Chen Yu-Jen Wu Ping-Jyun Sung
author_sort	Thanh-Hao Huynh
title	Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>
title_short	Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>
title_full	Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>
title_fullStr	Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>
title_full_unstemmed	Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>
title_sort	briarane-related diterpenoids from octocoral <i>briareum stechei</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/61b6a9b4de5c47f8ad4d9976248c1853
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Briarane-Related Diterpenoids from Octocoral <i>Briareum stechei</i>

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