Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

The effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT...

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Auteurs principaux:	Jeremy J. McGuire, Jeremy S. Frieling, Chen Hao Lo, Tao Li, Ayaz Muhammad, Harshani R. Lawrence, Nicholas J. Lawrence, Leah M. Cook, Conor C. Lynch
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/61b815bbfbe3485cb1696124b372aa50
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spelling	oai:doaj.org-article:61b815bbfbe3485cb1696124b372aa502021-12-02T14:06:28ZMesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer10.1038/s41467-021-20962-62041-1723https://doaj.org/article/61b815bbfbe3485cb1696124b372aa502021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20962-6https://doaj.org/toc/2041-1723The effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT3.Jeremy J. McGuireJeremy S. FrielingChen Hao LoTao LiAyaz MuhammadHarshani R. LawrenceNicholas J. LawrenceLeah M. CookConor C. LynchNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeremy J. McGuire Jeremy S. Frieling Chen Hao Lo Tao Li Ayaz Muhammad Harshani R. Lawrence Nicholas J. Lawrence Leah M. Cook Conor C. Lynch Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
description	The effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT3.
format	article
author	Jeremy J. McGuire Jeremy S. Frieling Chen Hao Lo Tao Li Ayaz Muhammad Harshani R. Lawrence Nicholas J. Lawrence Leah M. Cook Conor C. Lynch
author_facet	Jeremy J. McGuire Jeremy S. Frieling Chen Hao Lo Tao Li Ayaz Muhammad Harshani R. Lawrence Nicholas J. Lawrence Leah M. Cook Conor C. Lynch
author_sort	Jeremy J. McGuire
title	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_short	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_full	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_fullStr	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_full_unstemmed	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_sort	mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61b815bbfbe3485cb1696124b372aa50
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Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

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