Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

The effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT...

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Autores principales: Jeremy J. McGuire, Jeremy S. Frieling, Chen Hao Lo, Tao Li, Ayaz Muhammad, Harshani R. Lawrence, Nicholas J. Lawrence, Leah M. Cook, Conor C. Lynch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/61b815bbfbe3485cb1696124b372aa50
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