CyFi-MAP: an interactive pathway-based resource for cystic fibrosis
Abstract Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by more than 2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating variability in disease severity among individuals with CF sharing the same CFTR genotype. Systems biology can assis...
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Nature Portfolio
2021
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oai:doaj.org-article:61bb59c2153246c1a0ae7d255451f7f92021-11-21T12:18:10ZCyFi-MAP: an interactive pathway-based resource for cystic fibrosis10.1038/s41598-021-01618-32045-2322https://doaj.org/article/61bb59c2153246c1a0ae7d255451f7f92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01618-3https://doaj.org/toc/2045-2322Abstract Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by more than 2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating variability in disease severity among individuals with CF sharing the same CFTR genotype. Systems biology can assist in the collection and visualization of CF data to extract additional biological significance and find novel therapeutic targets. Here, we present the CyFi-MAP—a disease map repository of CFTR molecular mechanisms and pathways involved in CF. Specifically, we represented the wild-type (wt-CFTR) and the F508del associated processes (F508del-CFTR) in separate submaps, with pathways related to protein biosynthesis, endoplasmic reticulum retention, export, activation/inactivation of channel function, and recycling/degradation after endocytosis. CyFi-MAP is an open-access resource with specific, curated and continuously updated information on CFTR-related pathways available online at https://cysticfibrosismap.github.io/ . This tool was developed as a reference CF pathway data repository to be continuously updated and used worldwide in CF research.Catarina PereiraAlexander MazeinCarlos M. FarinhaMichael A. GrayKarl KunzelmannMarek OstaszewskiIrina BalaurMargarida D. AmaralAndre O. FalcaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021) |
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Medicine R Science Q Catarina Pereira Alexander Mazein Carlos M. Farinha Michael A. Gray Karl Kunzelmann Marek Ostaszewski Irina Balaur Margarida D. Amaral Andre O. Falcao CyFi-MAP: an interactive pathway-based resource for cystic fibrosis |
description |
Abstract Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by more than 2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating variability in disease severity among individuals with CF sharing the same CFTR genotype. Systems biology can assist in the collection and visualization of CF data to extract additional biological significance and find novel therapeutic targets. Here, we present the CyFi-MAP—a disease map repository of CFTR molecular mechanisms and pathways involved in CF. Specifically, we represented the wild-type (wt-CFTR) and the F508del associated processes (F508del-CFTR) in separate submaps, with pathways related to protein biosynthesis, endoplasmic reticulum retention, export, activation/inactivation of channel function, and recycling/degradation after endocytosis. CyFi-MAP is an open-access resource with specific, curated and continuously updated information on CFTR-related pathways available online at https://cysticfibrosismap.github.io/ . This tool was developed as a reference CF pathway data repository to be continuously updated and used worldwide in CF research. |
format |
article |
author |
Catarina Pereira Alexander Mazein Carlos M. Farinha Michael A. Gray Karl Kunzelmann Marek Ostaszewski Irina Balaur Margarida D. Amaral Andre O. Falcao |
author_facet |
Catarina Pereira Alexander Mazein Carlos M. Farinha Michael A. Gray Karl Kunzelmann Marek Ostaszewski Irina Balaur Margarida D. Amaral Andre O. Falcao |
author_sort |
Catarina Pereira |
title |
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis |
title_short |
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis |
title_full |
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis |
title_fullStr |
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis |
title_full_unstemmed |
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis |
title_sort |
cyfi-map: an interactive pathway-based resource for cystic fibrosis |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/61bb59c2153246c1a0ae7d255451f7f9 |
work_keys_str_mv |
AT catarinapereira cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT alexandermazein cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT carlosmfarinha cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT michaelagray cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT karlkunzelmann cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT marekostaszewski cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT irinabalaur cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT margaridadamaral cyfimapaninteractivepathwaybasedresourceforcysticfibrosis AT andreofalcao cyfimapaninteractivepathwaybasedresourceforcysticfibrosis |
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