The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.
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| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/61bf2407c8eb4a9eb5d46d59f18432bf |
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oai:doaj.org-article:61bf2407c8eb4a9eb5d46d59f18432bf2021-12-02T17:32:31ZThe critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance10.1038/s41467-018-07188-92041-1723https://doaj.org/article/61bf2407c8eb4a9eb5d46d59f18432bf2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07188-9https://doaj.org/toc/2041-1723How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.Fei HanChien-Feng LiZhen CaiXian ZhangGuoxiang JinWei-Na ZhangChuan XuChi-Yun WangJohn MorrowShuxing ZhangDazhi XuGuihua WangHui-Kuan LinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Fei Han Chien-Feng Li Zhen Cai Xian Zhang Guoxiang Jin Wei-Na Zhang Chuan Xu Chi-Yun Wang John Morrow Shuxing Zhang Dazhi Xu Guihua Wang Hui-Kuan Lin The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance |
| description |
How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1. |
| format |
article |
| author |
Fei Han Chien-Feng Li Zhen Cai Xian Zhang Guoxiang Jin Wei-Na Zhang Chuan Xu Chi-Yun Wang John Morrow Shuxing Zhang Dazhi Xu Guihua Wang Hui-Kuan Lin |
| author_facet |
Fei Han Chien-Feng Li Zhen Cai Xian Zhang Guoxiang Jin Wei-Na Zhang Chuan Xu Chi-Yun Wang John Morrow Shuxing Zhang Dazhi Xu Guihua Wang Hui-Kuan Lin |
| author_sort |
Fei Han |
| title |
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance |
| title_short |
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance |
| title_full |
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance |
| title_fullStr |
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance |
| title_full_unstemmed |
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance |
| title_sort |
critical role of ampk in driving akt activation under stress, tumorigenesis and drug resistance |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/61bf2407c8eb4a9eb5d46d59f18432bf |
| work_keys_str_mv |
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