The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.

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Detalles Bibliográficos
Autores principales: Fei Han, Chien-Feng Li, Zhen Cai, Xian Zhang, Guoxiang Jin, Wei-Na Zhang, Chuan Xu, Chi-Yun Wang, John Morrow, Shuxing Zhang, Dazhi Xu, Guihua Wang, Hui-Kuan Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/61bf2407c8eb4a9eb5d46d59f18432bf
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