Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease

Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease

ABSTRACT Pneumococcal pili have been shown to influence pneumococcal colonization, disease development, and the inflammatory response in mice. The role of the pilus-associated RrgA adhesin in pneumococcal interactions with murine and human macrophages was investigated. Expression of pili with RrgA e...

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Bibliographic Details
Main Authors: Sofia Orrskog, Samuli Rounioja, Tiziana Spadafina, Marilena Gallotta, Martin Norman, Karina Hentrich, Stefan Fälker, Sofia Ygberg-Eriksson, Mike Hasenberg, Björn Johansson, Liisa M. Uotila, Carl G. Gahmberg, Michèle Barocchi, Matthias Gunzer, Staffan Normark, Birgitta Henriques-Normark
Format: article
Language:EN
Published: American Society for Microbiology 2013
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/61bf47911139403a9c51ff45e75d9a80
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