Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer
Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire.
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Nature Portfolio
2021
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oai:doaj.org-article:61c0fcf9baf94acab6feccd225cfafb02021-11-21T12:36:00ZCold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer10.1038/s41467-021-26821-82041-1723https://doaj.org/article/61c0fcf9baf94acab6feccd225cfafb02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26821-8https://doaj.org/toc/2041-1723Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire.Ming ChenRunzhe ChenYing JinJun LiXin HuJiexin ZhangJunya FujimotoShawna M. HubertCarl M. GayBo ZhuYanhua TianNicholas McGranahanWon-Chul LeeJulie GeorgeXiao HuYamei ChenMeijuan WuCarmen BehrensChi-Wan ChowHoa H. N. PhamJunya FukuokaJia WuEdwin Roger ParraLatasha D. LittleCurtis GumbsXingzhi SongChang-Jiun WuLixia DiaoQi WangRobert CardnellJianhua ZhangJing WangXiuning LeDon L. GibbonsJohn V. HeymachJ. Jack LeeWilliam N. WilliamChao ChengBonnie GlissonIgnacio WistubaP. Andrew FutrealRoman K. ThomasAlexandre ReubenLauren A. ByersJianjun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ming Chen Runzhe Chen Ying Jin Jun Li Xin Hu Jiexin Zhang Junya Fujimoto Shawna M. Hubert Carl M. Gay Bo Zhu Yanhua Tian Nicholas McGranahan Won-Chul Lee Julie George Xiao Hu Yamei Chen Meijuan Wu Carmen Behrens Chi-Wan Chow Hoa H. N. Pham Junya Fukuoka Jia Wu Edwin Roger Parra Latasha D. Little Curtis Gumbs Xingzhi Song Chang-Jiun Wu Lixia Diao Qi Wang Robert Cardnell Jianhua Zhang Jing Wang Xiuning Le Don L. Gibbons John V. Heymach J. Jack Lee William N. William Chao Cheng Bonnie Glisson Ignacio Wistuba P. Andrew Futreal Roman K. Thomas Alexandre Reuben Lauren A. Byers Jianjun Zhang Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer |
| description |
Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire. |
| format |
article |
| author |
Ming Chen Runzhe Chen Ying Jin Jun Li Xin Hu Jiexin Zhang Junya Fujimoto Shawna M. Hubert Carl M. Gay Bo Zhu Yanhua Tian Nicholas McGranahan Won-Chul Lee Julie George Xiao Hu Yamei Chen Meijuan Wu Carmen Behrens Chi-Wan Chow Hoa H. N. Pham Junya Fukuoka Jia Wu Edwin Roger Parra Latasha D. Little Curtis Gumbs Xingzhi Song Chang-Jiun Wu Lixia Diao Qi Wang Robert Cardnell Jianhua Zhang Jing Wang Xiuning Le Don L. Gibbons John V. Heymach J. Jack Lee William N. William Chao Cheng Bonnie Glisson Ignacio Wistuba P. Andrew Futreal Roman K. Thomas Alexandre Reuben Lauren A. Byers Jianjun Zhang |
| author_facet |
Ming Chen Runzhe Chen Ying Jin Jun Li Xin Hu Jiexin Zhang Junya Fujimoto Shawna M. Hubert Carl M. Gay Bo Zhu Yanhua Tian Nicholas McGranahan Won-Chul Lee Julie George Xiao Hu Yamei Chen Meijuan Wu Carmen Behrens Chi-Wan Chow Hoa H. N. Pham Junya Fukuoka Jia Wu Edwin Roger Parra Latasha D. Little Curtis Gumbs Xingzhi Song Chang-Jiun Wu Lixia Diao Qi Wang Robert Cardnell Jianhua Zhang Jing Wang Xiuning Le Don L. Gibbons John V. Heymach J. Jack Lee William N. William Chao Cheng Bonnie Glisson Ignacio Wistuba P. Andrew Futreal Roman K. Thomas Alexandre Reuben Lauren A. Byers Jianjun Zhang |
| author_sort |
Ming Chen |
| title |
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer |
| title_short |
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer |
| title_full |
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer |
| title_fullStr |
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer |
| title_full_unstemmed |
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer |
| title_sort |
cold and heterogeneous t cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/61c0fcf9baf94acab6feccd225cfafb0 |
| work_keys_str_mv |
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