Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation

Intra- and interlimb coordination during locomotion is governed by hierarchically organized lumbar spinal networks. Here, the authors show that reversible silencing of spinal L2–L5 interneurons specifically disrupts hindlimb alternation leading to a continuum of walking to hopping.

Guardado en:

Detalles Bibliográficos
Autores principales:	Amanda M. Pocratsky, Darlene A. Burke, Johnny R. Morehouse, Jason E. Beare, Amberly S. Riegler, Pantelis Tsoulfas, Gregory J. R. States, Scott R. Whittemore, David S. K. Magnuson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61c12fdd45c24223be75489c98ecb5e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:61c12fdd45c24223be75489c98ecb5e8
record_format	dspace
spelling	oai:doaj.org-article:61c12fdd45c24223be75489c98ecb5e82021-12-02T13:24:23ZReversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation10.1038/s41467-017-02033-x2041-1723https://doaj.org/article/61c12fdd45c24223be75489c98ecb5e82017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02033-xhttps://doaj.org/toc/2041-1723Intra- and interlimb coordination during locomotion is governed by hierarchically organized lumbar spinal networks. Here, the authors show that reversible silencing of spinal L2–L5 interneurons specifically disrupts hindlimb alternation leading to a continuum of walking to hopping.Amanda M. PocratskyDarlene A. BurkeJohnny R. MorehouseJason E. BeareAmberly S. RieglerPantelis TsoulfasGregory J. R. StatesScott R. WhittemoreDavid S. K. MagnusonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amanda M. Pocratsky Darlene A. Burke Johnny R. Morehouse Jason E. Beare Amberly S. Riegler Pantelis Tsoulfas Gregory J. R. States Scott R. Whittemore David S. K. Magnuson Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation
description	Intra- and interlimb coordination during locomotion is governed by hierarchically organized lumbar spinal networks. Here, the authors show that reversible silencing of spinal L2–L5 interneurons specifically disrupts hindlimb alternation leading to a continuum of walking to hopping.
format	article
author	Amanda M. Pocratsky Darlene A. Burke Johnny R. Morehouse Jason E. Beare Amberly S. Riegler Pantelis Tsoulfas Gregory J. R. States Scott R. Whittemore David S. K. Magnuson
author_facet	Amanda M. Pocratsky Darlene A. Burke Johnny R. Morehouse Jason E. Beare Amberly S. Riegler Pantelis Tsoulfas Gregory J. R. States Scott R. Whittemore David S. K. Magnuson
author_sort	Amanda M. Pocratsky
title	Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation
title_short	Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation
title_full	Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation
title_fullStr	Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation
title_full_unstemmed	Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation
title_sort	reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/61c12fdd45c24223be75489c98ecb5e8
work_keys_str_mv	AT amandampocratsky reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT darleneaburke reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT johnnyrmorehouse reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT jasonebeare reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT amberlysriegler reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT pantelistsoulfas reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT gregoryjrstates reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT scottrwhittemore reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation AT davidskmagnuson reversiblesilencingoflumbarspinalinterneuronsunmasksataskspecificnetworkforsecuringhindlimbalternation
_version_	1718393096852471808

Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation

Ejemplares similares