An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development

Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic since March 2020 and led to significant challenges to over 200 countries and regions all over the world. The establishment of highly pathogenic coronavirus animal model is...

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Autores principales:	Liang Zhang, Shuaiyin Chen, Weiguo Zhang, Haiyan Yang, Yuefei Jin, Guangcai Duan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 SARS-CoV-2 ACE2 infection animal model Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/61c28ebd85444102a98053ddaaf0bb77
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spelling	oai:doaj.org-article:61c28ebd85444102a98053ddaaf0bb772021-11-08T07:36:57ZAn Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development1664-302X10.3389/fmicb.2021.770935https://doaj.org/article/61c28ebd85444102a98053ddaaf0bb772021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.770935/fullhttps://doaj.org/toc/1664-302XCoronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic since March 2020 and led to significant challenges to over 200 countries and regions all over the world. The establishment of highly pathogenic coronavirus animal model is beneficial for the study of vaccines and pathogenic mechanism of the virus. Laboratory mice, Syrian hamsters, Non-human primates and Ferrets have been used to establish animal models of emerging coronavirus infection. Different animal models can reproduce clinical infection symptoms at different levels. Appropriate animal models are of great significance for the pathogenesis of COVID-19 and the research progress related to vaccines. This review aims to introduce the current progress about experimental animal models for SARS-CoV-2, and collectively generalize critical aspects of disease manifestation in humans and increase their usefulness in research into COVID-19 pathogenesis and developing new preventions and treatments.Liang ZhangShuaiyin ChenWeiguo ZhangWeiguo ZhangHaiyan YangYuefei JinGuangcai DuanGuangcai DuanFrontiers Media S.A.articleCOVID-19SARS-CoV-2ACE2infectionanimal modelMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 ACE2 infection animal model Microbiology QR1-502
spellingShingle	COVID-19 SARS-CoV-2 ACE2 infection animal model Microbiology QR1-502 Liang Zhang Shuaiyin Chen Weiguo Zhang Weiguo Zhang Haiyan Yang Yuefei Jin Guangcai Duan Guangcai Duan An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development
description	Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic since March 2020 and led to significant challenges to over 200 countries and regions all over the world. The establishment of highly pathogenic coronavirus animal model is beneficial for the study of vaccines and pathogenic mechanism of the virus. Laboratory mice, Syrian hamsters, Non-human primates and Ferrets have been used to establish animal models of emerging coronavirus infection. Different animal models can reproduce clinical infection symptoms at different levels. Appropriate animal models are of great significance for the pathogenesis of COVID-19 and the research progress related to vaccines. This review aims to introduce the current progress about experimental animal models for SARS-CoV-2, and collectively generalize critical aspects of disease manifestation in humans and increase their usefulness in research into COVID-19 pathogenesis and developing new preventions and treatments.
format	article
author	Liang Zhang Shuaiyin Chen Weiguo Zhang Weiguo Zhang Haiyan Yang Yuefei Jin Guangcai Duan Guangcai Duan
author_facet	Liang Zhang Shuaiyin Chen Weiguo Zhang Weiguo Zhang Haiyan Yang Yuefei Jin Guangcai Duan Guangcai Duan
author_sort	Liang Zhang
title	An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development
title_short	An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development
title_full	An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development
title_fullStr	An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development
title_full_unstemmed	An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development
title_sort	update on animal models for severe acute respiratory syndrome coronavirus 2 infection and countermeasure development
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/61c28ebd85444102a98053ddaaf0bb77
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An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development

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