Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

It is unclear how resident p16-expressing senescent cells affect the propensity of tissues to develop cancer. Here, the authors show that chronic p16 expression in the mouse epidermis causes hyperplasia and dysplasia through Wnt-mediated paracrine stimulation of proliferating keratinocytes, and can...

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Autores principales:	Narmen Azazmeh, Benjamin Assouline, Eitan Winter, Shmuel Ruppo, Yuval Nevo, Alexander Maly, Karen Meir, Agnieszka K. Witkiewicz, Jonathan Cohen, Sophia V. Rizou, Eli Pikarsky, Chen Luxenburg, Vassilis G. Gorgoulis, Ittai Ben-Porath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61ce1bf5407c4803ae109b815ded6484
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spelling	oai:doaj.org-article:61ce1bf5407c4803ae109b815ded64842021-12-02T17:50:39ZChronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation10.1038/s41467-020-16475-32041-1723https://doaj.org/article/61ce1bf5407c4803ae109b815ded64842020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16475-3https://doaj.org/toc/2041-1723It is unclear how resident p16-expressing senescent cells affect the propensity of tissues to develop cancer. Here, the authors show that chronic p16 expression in the mouse epidermis causes hyperplasia and dysplasia through Wnt-mediated paracrine stimulation of proliferating keratinocytes, and can contribute to tumour formation.Narmen AzazmehBenjamin AssoulineEitan WinterShmuel RuppoYuval NevoAlexander MalyKaren MeirAgnieszka K. WitkiewiczJonathan CohenSophia V. RizouEli PikarskyChen LuxenburgVassilis G. GorgoulisIttai Ben-PorathNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Narmen Azazmeh Benjamin Assouline Eitan Winter Shmuel Ruppo Yuval Nevo Alexander Maly Karen Meir Agnieszka K. Witkiewicz Jonathan Cohen Sophia V. Rizou Eli Pikarsky Chen Luxenburg Vassilis G. Gorgoulis Ittai Ben-Porath Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
description	It is unclear how resident p16-expressing senescent cells affect the propensity of tissues to develop cancer. Here, the authors show that chronic p16 expression in the mouse epidermis causes hyperplasia and dysplasia through Wnt-mediated paracrine stimulation of proliferating keratinocytes, and can contribute to tumour formation.
format	article
author	Narmen Azazmeh Benjamin Assouline Eitan Winter Shmuel Ruppo Yuval Nevo Alexander Maly Karen Meir Agnieszka K. Witkiewicz Jonathan Cohen Sophia V. Rizou Eli Pikarsky Chen Luxenburg Vassilis G. Gorgoulis Ittai Ben-Porath
author_facet	Narmen Azazmeh Benjamin Assouline Eitan Winter Shmuel Ruppo Yuval Nevo Alexander Maly Karen Meir Agnieszka K. Witkiewicz Jonathan Cohen Sophia V. Rizou Eli Pikarsky Chen Luxenburg Vassilis G. Gorgoulis Ittai Ben-Porath
author_sort	Narmen Azazmeh
title	Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
title_short	Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
title_full	Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
title_fullStr	Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
title_full_unstemmed	Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
title_sort	chronic expression of p16ink4a in the epidermis induces wnt-mediated hyperplasia and promotes tumor initiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/61ce1bf5407c4803ae109b815ded6484
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Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

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