Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer

Introduction: Despite extensive research and development, potentially malignant disorders (PMDs) of the oral cavity and oral cancer remain a serious concern. Diet and immunity have been identified as important modifiable factors in such diseases. Materials and Methods: A total of 20 patients and 10...

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Autores principales:	Mathew O Mampilly, Nidhi Ravindran, Mohamed Shajith Parambil, Kumar Nilesh, Parvathi Jayagopalan, Debjit Dhamali
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	antigen-antibody complex ceruloplasmin mouth neoplasm's selenium Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/61cf246d11b548e59c7de47a09663f91
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spelling	oai:doaj.org-article:61cf246d11b548e59c7de47a09663f912021-11-19T12:15:51ZAssessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer0975-740610.4103/jpbs.jpbs_380_21https://doaj.org/article/61cf246d11b548e59c7de47a09663f912021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=989;epage=992;aulast=Mampillyhttps://doaj.org/toc/0975-7406Introduction: Despite extensive research and development, potentially malignant disorders (PMDs) of the oral cavity and oral cancer remain a serious concern. Diet and immunity have been identified as important modifiable factors in such diseases. Materials and Methods: A total of 20 patients and 10 healthy individuals, aged 30–60 years, were chosen from the outpatient Department of Oral and Maxillofacial Surgery, Yenepoya Dental College and hospital, Karnataka. The participants were grouped into three: Group 1: (10 healthy individuals), Group 2: (10 oral leukoplakia patients) and Group 3: (10 squamous cell carcinoma patients). Blood was chosen as the investigative medium. Ceruloplasmin was estimated by the diamine oxidase method. The technique of atomic absorption developed by Sir Alan Walsh in 1950 has become the preferred method of elemental analysis of selenium (atomic absorption spectrometer). Statistical analysis of the data obtained was done using one-way ANOVA test and the Turkey multiple comparisons test. Results: The intergroup comparison of ceruloplasmin shows that the mean value of Group I (Control) was 31.746 mg/dl, the mean value of Group II (leukoplakia) was 81.411 mg/dl, and the mean value of Group III (squamous cell carcinoma) was 90.7120 mg/dl. The intergroup comparison of selenium levels shows that the mean value of Group I (Control) was 119.937 (ng/ml), the mean value of Group II (leukoplakia) was 109.17 (ng/ml), and the mean value of Group III (squamous cell carcinoma) was 99.6230 (ng/ml). Conclusion: Antioxidants are an important defense system against free radical damage to cells. Ceruloplasmin and selenium levels in serum could be used as disease markers in leukoplakia and squamous cell carcinoma.Mathew O MampillyNidhi RavindranMohamed Shajith ParambilKumar NileshParvathi JayagopalanDebjit DhamaliWolters Kluwer Medknow Publicationsarticleantigen-antibody complexceruloplasminmouth neoplasm'sseleniumPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 989-992 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antigen-antibody complex ceruloplasmin mouth neoplasm's selenium Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	antigen-antibody complex ceruloplasmin mouth neoplasm's selenium Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Mathew O Mampilly Nidhi Ravindran Mohamed Shajith Parambil Kumar Nilesh Parvathi Jayagopalan Debjit Dhamali Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
description	Introduction: Despite extensive research and development, potentially malignant disorders (PMDs) of the oral cavity and oral cancer remain a serious concern. Diet and immunity have been identified as important modifiable factors in such diseases. Materials and Methods: A total of 20 patients and 10 healthy individuals, aged 30–60 years, were chosen from the outpatient Department of Oral and Maxillofacial Surgery, Yenepoya Dental College and hospital, Karnataka. The participants were grouped into three: Group 1: (10 healthy individuals), Group 2: (10 oral leukoplakia patients) and Group 3: (10 squamous cell carcinoma patients). Blood was chosen as the investigative medium. Ceruloplasmin was estimated by the diamine oxidase method. The technique of atomic absorption developed by Sir Alan Walsh in 1950 has become the preferred method of elemental analysis of selenium (atomic absorption spectrometer). Statistical analysis of the data obtained was done using one-way ANOVA test and the Turkey multiple comparisons test. Results: The intergroup comparison of ceruloplasmin shows that the mean value of Group I (Control) was 31.746 mg/dl, the mean value of Group II (leukoplakia) was 81.411 mg/dl, and the mean value of Group III (squamous cell carcinoma) was 90.7120 mg/dl. The intergroup comparison of selenium levels shows that the mean value of Group I (Control) was 119.937 (ng/ml), the mean value of Group II (leukoplakia) was 109.17 (ng/ml), and the mean value of Group III (squamous cell carcinoma) was 99.6230 (ng/ml). Conclusion: Antioxidants are an important defense system against free radical damage to cells. Ceruloplasmin and selenium levels in serum could be used as disease markers in leukoplakia and squamous cell carcinoma.
format	article
author	Mathew O Mampilly Nidhi Ravindran Mohamed Shajith Parambil Kumar Nilesh Parvathi Jayagopalan Debjit Dhamali
author_facet	Mathew O Mampilly Nidhi Ravindran Mohamed Shajith Parambil Kumar Nilesh Parvathi Jayagopalan Debjit Dhamali
author_sort	Mathew O Mampilly
title	Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
title_short	Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
title_full	Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
title_fullStr	Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
title_full_unstemmed	Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
title_sort	assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/61cf246d11b548e59c7de47a09663f91
work_keys_str_mv	AT mathewomampilly assessmentofserumseleniumandceruloplasmininpotentiallymalignantdisordersandoralcancer AT nidhiravindran assessmentofserumseleniumandceruloplasmininpotentiallymalignantdisordersandoralcancer AT mohamedshajithparambil assessmentofserumseleniumandceruloplasmininpotentiallymalignantdisordersandoralcancer AT kumarnilesh assessmentofserumseleniumandceruloplasmininpotentiallymalignantdisordersandoralcancer AT parvathijayagopalan assessmentofserumseleniumandceruloplasmininpotentiallymalignantdisordersandoralcancer AT debjitdhamali assessmentofserumseleniumandceruloplasmininpotentiallymalignantdisordersandoralcancer
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Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer

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