Functional analysis of Hsp70 inhibitors.
The molecular chaperones of the Hsp70 family have been recognized as targets for anti-cancer therapy. Since several paralogs of Hsp70 proteins exist in cytosol, endoplasmic reticulum and mitochondria, we investigated which isoform needs to be down-regulated for reducing viability of cancer cells. Fo...
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Autores principales: | Rainer Schlecht, Sebastian R Scholz, Heike Dahmen, Ansgar Wegener, Christian Sirrenberg, Djordje Musil, Joerg Bomke, Hans-Michael Eggenweiler, Matthias P Mayer, Bernd Bukau |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/61d0e4e74a9e4efa87d2fb910f1f8022 |
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