Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture

Background Subclinical infection of cardiac implantable electronic devices (CIEDs) is a common condition and increases the risk of clinical infection. However, there are limited studies focused on risk stratifying and prognostic analysis of subclinical CIED infection. Methods and Results Data from 4...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gaofeng Lin, Tong Zou, Min Dong, Junpeng Liu, Wen Cui, Jiabin Tong, Haifeng Shi, Hao Chen, Jia Chong, You Lyu, Sujuan Wu, Zhilei Wang, Xin Jin, Xu Gao, Lin Sun, Yimei Qu, Jiefu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bacterial culture cardiac implantable electronic devices prognosis risk stratifying subclinical infection Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/61d11fe4de4d434ca65e8deb1cde1a52
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:61d11fe4de4d434ca65e8deb1cde1a52
record_format	dspace
spelling	oai:doaj.org-article:61d11fe4de4d434ca65e8deb1cde1a522021-11-16T10:22:43ZRisk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture10.1161/JAHA.121.0222602047-9980https://doaj.org/article/61d11fe4de4d434ca65e8deb1cde1a522021-11-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.121.022260https://doaj.org/toc/2047-9980Background Subclinical infection of cardiac implantable electronic devices (CIEDs) is a common condition and increases the risk of clinical infection. However, there are limited studies focused on risk stratifying and prognostic analysis of subclinical CIED infection. Methods and Results Data from 418 consecutive patients undergoing CIED replacement or upgrade between January 2011 and December 2019 were used in the analysis. Among the patients included, 50 (12.0%) were detected as positive by bacterial culture of pocket tissues. The most frequently isolated bacteria were coagulase‐negative staphylococci (76.9%). Compared with the noninfection group, more patients in the subclinical infection group were taking immunosuppressive agents, received electrode replacement, or received CIED upgrade and temporary pacing. Patients in the subclinical infection group had a higher PADIT (Prevention of Arrhythmia Device Infection Trial) score. Univariable and multivariable logistic regression analysis found that use of immunosuppressive agents (odds ratio [OR], 6.95 [95% CI, 1.44–33.51]; P=0.02) and electrode replacement or CIED upgrade (OR, 6.73 [95% CI, 2.23–20.38]; P=0.001) were significantly associated with subclinical CIED infection. Meanwhile, compared with the low‐risk group, patients in the intermediate/high‐risk group had a higher risk of subclinical CIED infection (OR, 3.43 [95% CI, 1.58–7.41]; P=0.002). After a median follow‐up time of 36.5 months, the end points between the subclinical infection group and noninfection group were as follows: composite events (58.0% versus 41.8%, P=0.03), rehospitalization (54.0% versus 32.1%, P=0.002), cardiovascular rehospitalization (32.0% versus 13.9%, P=0.001), CIED infection (2.0% versus 0.5%, P=0.32), all‐cause mortality (28.0% versus 21.5%, P=0.30), and cardiovascular mortality (10.0% versus 7.6%, P=0.57). Conclusions Subclinical CIED infection was a common phenomenon. The PADIT score had significant value for stratifying patients at high risk of subclinical CIED infection. Subclinical CIED infection was associated with increased risks of composite events, rehospitalization, and cardiovascular rehospitalization.Gaofeng LinTong ZouMin DongJunpeng LiuWen CuiJiabin TongHaifeng ShiHao ChenJia ChongYou LyuSujuan WuZhilei WangXin JinXu GaoLin SunYimei QuJiefu YangWileyarticlebacterial culturecardiac implantable electronic devicesprognosisrisk stratifyingsubclinical infectionDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacterial culture cardiac implantable electronic devices prognosis risk stratifying subclinical infection Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	bacterial culture cardiac implantable electronic devices prognosis risk stratifying subclinical infection Diseases of the circulatory (Cardiovascular) system RC666-701 Gaofeng Lin Tong Zou Min Dong Junpeng Liu Wen Cui Jiabin Tong Haifeng Shi Hao Chen Jia Chong You Lyu Sujuan Wu Zhilei Wang Xin Jin Xu Gao Lin Sun Yimei Qu Jiefu Yang Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture
description	Background Subclinical infection of cardiac implantable electronic devices (CIEDs) is a common condition and increases the risk of clinical infection. However, there are limited studies focused on risk stratifying and prognostic analysis of subclinical CIED infection. Methods and Results Data from 418 consecutive patients undergoing CIED replacement or upgrade between January 2011 and December 2019 were used in the analysis. Among the patients included, 50 (12.0%) were detected as positive by bacterial culture of pocket tissues. The most frequently isolated bacteria were coagulase‐negative staphylococci (76.9%). Compared with the noninfection group, more patients in the subclinical infection group were taking immunosuppressive agents, received electrode replacement, or received CIED upgrade and temporary pacing. Patients in the subclinical infection group had a higher PADIT (Prevention of Arrhythmia Device Infection Trial) score. Univariable and multivariable logistic regression analysis found that use of immunosuppressive agents (odds ratio [OR], 6.95 [95% CI, 1.44–33.51]; P=0.02) and electrode replacement or CIED upgrade (OR, 6.73 [95% CI, 2.23–20.38]; P=0.001) were significantly associated with subclinical CIED infection. Meanwhile, compared with the low‐risk group, patients in the intermediate/high‐risk group had a higher risk of subclinical CIED infection (OR, 3.43 [95% CI, 1.58–7.41]; P=0.002). After a median follow‐up time of 36.5 months, the end points between the subclinical infection group and noninfection group were as follows: composite events (58.0% versus 41.8%, P=0.03), rehospitalization (54.0% versus 32.1%, P=0.002), cardiovascular rehospitalization (32.0% versus 13.9%, P=0.001), CIED infection (2.0% versus 0.5%, P=0.32), all‐cause mortality (28.0% versus 21.5%, P=0.30), and cardiovascular mortality (10.0% versus 7.6%, P=0.57). Conclusions Subclinical CIED infection was a common phenomenon. The PADIT score had significant value for stratifying patients at high risk of subclinical CIED infection. Subclinical CIED infection was associated with increased risks of composite events, rehospitalization, and cardiovascular rehospitalization.
format	article
author	Gaofeng Lin Tong Zou Min Dong Junpeng Liu Wen Cui Jiabin Tong Haifeng Shi Hao Chen Jia Chong You Lyu Sujuan Wu Zhilei Wang Xin Jin Xu Gao Lin Sun Yimei Qu Jiefu Yang
author_facet	Gaofeng Lin Tong Zou Min Dong Junpeng Liu Wen Cui Jiabin Tong Haifeng Shi Hao Chen Jia Chong You Lyu Sujuan Wu Zhilei Wang Xin Jin Xu Gao Lin Sun Yimei Qu Jiefu Yang
author_sort	Gaofeng Lin
title	Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture
title_short	Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture
title_full	Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture
title_fullStr	Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture
title_full_unstemmed	Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture
title_sort	risk stratifying and prognostic analysis of subclinical cardiac implantable electronic devices infection: insight from traditional bacterial culture
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/61d11fe4de4d434ca65e8deb1cde1a52
work_keys_str_mv	AT gaofenglin riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT tongzou riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT mindong riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT junpengliu riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT wencui riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT jiabintong riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT haifengshi riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT haochen riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT jiachong riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT youlyu riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT sujuanwu riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT zhileiwang riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT xinjin riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT xugao riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT linsun riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT yimeiqu riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture AT jiefuyang riskstratifyingandprognosticanalysisofsubclinicalcardiacimplantableelectronicdevicesinfectioninsightfromtraditionalbacterialculture
_version_	1718426550839279616

Risk Stratifying and Prognostic Analysis of Subclinical Cardiac Implantable Electronic Devices Infection: Insight From Traditional Bacterial Culture

Ejemplares similares