Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.

Fluctuating asymmetry (FA), a measure of developmental instability, has been hypothesized to increase with genetic stress. Despite numerous studies providing empirical evidence for associations between FA and genome-wide properties such as multi-locus heterozygosity, support for single-locus effects...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carl Vangestel, Joachim Mergeay, Deborah A Dawson, Viki Vandomme, Luc Lens
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61d2f1d5144340c7aa761c806a9b8e3c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:61d2f1d5144340c7aa761c806a9b8e3c
record_format	dspace
spelling	oai:doaj.org-article:61d2f1d5144340c7aa761c806a9b8e3c2021-11-18T06:50:50ZDevelopmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.1932-620310.1371/journal.pone.0021569https://doaj.org/article/61d2f1d5144340c7aa761c806a9b8e3c2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21747940/?tool=EBIhttps://doaj.org/toc/1932-6203Fluctuating asymmetry (FA), a measure of developmental instability, has been hypothesized to increase with genetic stress. Despite numerous studies providing empirical evidence for associations between FA and genome-wide properties such as multi-locus heterozygosity, support for single-locus effects remains scant. Here we test if, and to what extent, FA co-varies with single- and multilocus markers of genetic diversity in house sparrow (Passer domesticus) populations along an urban gradient. In line with theoretical expectations, FA was inversely correlated with genetic diversity estimated at genome level. However, this relationship was largely driven by variation at a single key locus. Contrary to our expectations, relationships between FA and genetic diversity were not stronger in individuals from urban populations that experience higher nutritional stress. We conclude that loss of genetic diversity adversely affects developmental stability in P. domesticus, and more generally, that the molecular basis of developmental stability may involve complex interactions between local and genome-wide effects. Further study on the relative effects of single-locus and genome-wide effects on the developmental stability of populations with different genetic properties is therefore needed.Carl VangestelJoachim MergeayDeborah A DawsonViki VandommeLuc LensPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21569 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carl Vangestel Joachim Mergeay Deborah A Dawson Viki Vandomme Luc Lens Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.
description	Fluctuating asymmetry (FA), a measure of developmental instability, has been hypothesized to increase with genetic stress. Despite numerous studies providing empirical evidence for associations between FA and genome-wide properties such as multi-locus heterozygosity, support for single-locus effects remains scant. Here we test if, and to what extent, FA co-varies with single- and multilocus markers of genetic diversity in house sparrow (Passer domesticus) populations along an urban gradient. In line with theoretical expectations, FA was inversely correlated with genetic diversity estimated at genome level. However, this relationship was largely driven by variation at a single key locus. Contrary to our expectations, relationships between FA and genetic diversity were not stronger in individuals from urban populations that experience higher nutritional stress. We conclude that loss of genetic diversity adversely affects developmental stability in P. domesticus, and more generally, that the molecular basis of developmental stability may involve complex interactions between local and genome-wide effects. Further study on the relative effects of single-locus and genome-wide effects on the developmental stability of populations with different genetic properties is therefore needed.
format	article
author	Carl Vangestel Joachim Mergeay Deborah A Dawson Viki Vandomme Luc Lens
author_facet	Carl Vangestel Joachim Mergeay Deborah A Dawson Viki Vandomme Luc Lens
author_sort	Carl Vangestel
title	Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.
title_short	Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.
title_full	Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.
title_fullStr	Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.
title_full_unstemmed	Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.
title_sort	developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/61d2f1d5144340c7aa761c806a9b8e3c
work_keys_str_mv	AT carlvangestel developmentalstabilitycovarieswithgenomewideandsinglelocusheterozygosityinhousesparrows AT joachimmergeay developmentalstabilitycovarieswithgenomewideandsinglelocusheterozygosityinhousesparrows AT deborahadawson developmentalstabilitycovarieswithgenomewideandsinglelocusheterozygosityinhousesparrows AT vikivandomme developmentalstabilitycovarieswithgenomewideandsinglelocusheterozygosityinhousesparrows AT luclens developmentalstabilitycovarieswithgenomewideandsinglelocusheterozygosityinhousesparrows
_version_	1718424295309312000

Developmental stability covaries with genome-wide and single-locus heterozygosity in house sparrows.

Ejemplares similares