Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia

Abstract Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofronta...

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Autores principales:	Shuichi Isomura, Ryota Hashimoto, Motoaki Nakamura, Yoji Hirano, Fumio Yamashita, Shin Jimbo, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Ryan P. Mears, Toshiaki Onitsuka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/61d45068fca742eca20fceb0c02788be
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spelling	oai:doaj.org-article:61d45068fca742eca20fceb0c02788be2021-12-02T15:18:49ZAltered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia10.1038/s41537-016-0008-y2334-265Xhttps://doaj.org/article/61d45068fca742eca20fceb0c02788be2017-01-01T00:00:00Zhttps://doi.org/10.1038/s41537-016-0008-yhttps://doaj.org/toc/2334-265XAbstract Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small–medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (χ 2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (χ 2 = 6.76, p = 0.009) and increased Type II expression (χ 2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.Shuichi IsomuraRyota HashimotoMotoaki NakamuraYoji HiranoFumio YamashitaShin JimboHidenaga YamamoriMichiko FujimotoYuka YasudaRyan P. MearsToshiaki OnitsukaNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Shuichi Isomura Ryota Hashimoto Motoaki Nakamura Yoji Hirano Fumio Yamashita Shin Jimbo Hidenaga Yamamori Michiko Fujimoto Yuka Yasuda Ryan P. Mears Toshiaki Onitsuka Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
description	Abstract Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small–medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (χ 2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (χ 2 = 6.76, p = 0.009) and increased Type II expression (χ 2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.
format	article
author	Shuichi Isomura Ryota Hashimoto Motoaki Nakamura Yoji Hirano Fumio Yamashita Shin Jimbo Hidenaga Yamamori Michiko Fujimoto Yuka Yasuda Ryan P. Mears Toshiaki Onitsuka
author_facet	Shuichi Isomura Ryota Hashimoto Motoaki Nakamura Yoji Hirano Fumio Yamashita Shin Jimbo Hidenaga Yamamori Michiko Fujimoto Yuka Yasuda Ryan P. Mears Toshiaki Onitsuka
author_sort	Shuichi Isomura
title	Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
title_short	Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
title_full	Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
title_fullStr	Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
title_full_unstemmed	Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
title_sort	altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/61d45068fca742eca20fceb0c02788be
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Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia

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