Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae

Mycoplasma pneumoniae infection often causes respiratory diseases in humans, particularly in children and adults with atypical pneumonia and community-acquired pneumonia (CAP), and is often exacerbated by co-infection with other lung diseases, such as asthma, bronchitis, and chronic obstructive pulm...

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Autores principales:	Xiaoling Su, Xiaoxing You, Haodang Luo, Keying Liang, Li Chen, Wei Tian, Zufeng Ye, Jun He
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	community acquired respiratory distress syndrome toxin Mycoplasma pneumoniae ADP-ribosyltransferase vacuolization asthma Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/61d95193efa349ccac95c02ad32cbcd3
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spelling	oai:doaj.org-article:61d95193efa349ccac95c02ad32cbcd32021-11-19T06:47:41ZCommunity-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae1664-302X10.3389/fmicb.2021.766591https://doaj.org/article/61d95193efa349ccac95c02ad32cbcd32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.766591/fullhttps://doaj.org/toc/1664-302XMycoplasma pneumoniae infection often causes respiratory diseases in humans, particularly in children and adults with atypical pneumonia and community-acquired pneumonia (CAP), and is often exacerbated by co-infection with other lung diseases, such as asthma, bronchitis, and chronic obstructive pulmonary disorder. Community-acquired respiratory distress syndrome toxin (CARDS TX) is the only exotoxin produced by M. pneumoniae and has been extensively studied for its ADP-ribosyltransferase (ADPRT) activity and cellular vacuolization properties. Additionally, CARDS TX induces inflammatory responses, resulting in cell swelling, nuclear lysis, mucus proliferation, and cell vacuolization. CARDS TX enters host cells by binding to the host receptor and is then reverse transported to the endoplasmic reticulum to exert its pathogenic effects. In this review, we focus on the structural characteristics, functional activity, distribution and receptors, mechanism of cell entry, and inflammatory response of CARDS TX was examined. Overall, the findings of this review provide a theoretical basis for further investigation of the mechanism of M. pneumoniae infection and the development of clinical diagnosis and vaccines.Xiaoling SuXiaoxing YouHaodang LuoKeying LiangLi ChenWei TianZufeng YeJun HeFrontiers Media S.A.articlecommunity acquired respiratory distress syndrome toxinMycoplasma pneumoniaeADP-ribosyltransferasevacuolizationasthmaMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	community acquired respiratory distress syndrome toxin Mycoplasma pneumoniae ADP-ribosyltransferase vacuolization asthma Microbiology QR1-502
spellingShingle	community acquired respiratory distress syndrome toxin Mycoplasma pneumoniae ADP-ribosyltransferase vacuolization asthma Microbiology QR1-502 Xiaoling Su Xiaoxing You Haodang Luo Keying Liang Li Chen Wei Tian Zufeng Ye Jun He Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae
description	Mycoplasma pneumoniae infection often causes respiratory diseases in humans, particularly in children and adults with atypical pneumonia and community-acquired pneumonia (CAP), and is often exacerbated by co-infection with other lung diseases, such as asthma, bronchitis, and chronic obstructive pulmonary disorder. Community-acquired respiratory distress syndrome toxin (CARDS TX) is the only exotoxin produced by M. pneumoniae and has been extensively studied for its ADP-ribosyltransferase (ADPRT) activity and cellular vacuolization properties. Additionally, CARDS TX induces inflammatory responses, resulting in cell swelling, nuclear lysis, mucus proliferation, and cell vacuolization. CARDS TX enters host cells by binding to the host receptor and is then reverse transported to the endoplasmic reticulum to exert its pathogenic effects. In this review, we focus on the structural characteristics, functional activity, distribution and receptors, mechanism of cell entry, and inflammatory response of CARDS TX was examined. Overall, the findings of this review provide a theoretical basis for further investigation of the mechanism of M. pneumoniae infection and the development of clinical diagnosis and vaccines.
format	article
author	Xiaoling Su Xiaoxing You Haodang Luo Keying Liang Li Chen Wei Tian Zufeng Ye Jun He
author_facet	Xiaoling Su Xiaoxing You Haodang Luo Keying Liang Li Chen Wei Tian Zufeng Ye Jun He
author_sort	Xiaoling Su
title	Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae
title_short	Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae
title_full	Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae
title_fullStr	Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae
title_full_unstemmed	Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae
title_sort	community-acquired respiratory distress syndrome toxin: unique exotoxin for m. pneumoniae
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/61d95193efa349ccac95c02ad32cbcd3
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Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae

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