S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Vaccines for SARS-CoV-2 are needed to fight the pandemic. Here the authors show immunogenicity of an adjuvanted subunit vaccine, SARS-CoV-2 spike protein trimerized with trimer-tag technology, in small animal models and protection from SARS-CoV-2 challenge in non-human primates.

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Autores principales:	Joshua G. Liang, Danmei Su, Tian-Zhang Song, Yilan Zeng, Weijin Huang, Jinhua Wu, Rong Xu, Peiwen Luo, Xiaofang Yang, Xiaodong Zhang, Shuangru Luo, Ying Liang, Xinglin Li, Jiaju Huang, Qiang Wang, Xueqin Huang, Qingsong Xu, Mei Luo, Anliang Huang, Dongxia Luo, Chenyan Zhao, Fan Yang, Jian-Bao Han, Yong-Tang Zheng, Peng Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61db57e69d5a405e82b86f6070a7345d
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spelling	oai:doaj.org-article:61db57e69d5a405e82b86f6070a7345d2021-12-02T13:34:48ZS-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates10.1038/s41467-021-21634-12041-1723https://doaj.org/article/61db57e69d5a405e82b86f6070a7345d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21634-1https://doaj.org/toc/2041-1723Vaccines for SARS-CoV-2 are needed to fight the pandemic. Here the authors show immunogenicity of an adjuvanted subunit vaccine, SARS-CoV-2 spike protein trimerized with trimer-tag technology, in small animal models and protection from SARS-CoV-2 challenge in non-human primates.Joshua G. LiangDanmei SuTian-Zhang SongYilan ZengWeijin HuangJinhua WuRong XuPeiwen LuoXiaofang YangXiaodong ZhangShuangru LuoYing LiangXinglin LiJiaju HuangQiang WangXueqin HuangQingsong XuMei LuoAnliang HuangDongxia LuoChenyan ZhaoFan YangJian-Bao HanYong-Tang ZhengPeng LiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua G. Liang Danmei Su Tian-Zhang Song Yilan Zeng Weijin Huang Jinhua Wu Rong Xu Peiwen Luo Xiaofang Yang Xiaodong Zhang Shuangru Luo Ying Liang Xinglin Li Jiaju Huang Qiang Wang Xueqin Huang Qingsong Xu Mei Luo Anliang Huang Dongxia Luo Chenyan Zhao Fan Yang Jian-Bao Han Yong-Tang Zheng Peng Liang S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
description	Vaccines for SARS-CoV-2 are needed to fight the pandemic. Here the authors show immunogenicity of an adjuvanted subunit vaccine, SARS-CoV-2 spike protein trimerized with trimer-tag technology, in small animal models and protection from SARS-CoV-2 challenge in non-human primates.
format	article
author	Joshua G. Liang Danmei Su Tian-Zhang Song Yilan Zeng Weijin Huang Jinhua Wu Rong Xu Peiwen Luo Xiaofang Yang Xiaodong Zhang Shuangru Luo Ying Liang Xinglin Li Jiaju Huang Qiang Wang Xueqin Huang Qingsong Xu Mei Luo Anliang Huang Dongxia Luo Chenyan Zhao Fan Yang Jian-Bao Han Yong-Tang Zheng Peng Liang
author_facet	Joshua G. Liang Danmei Su Tian-Zhang Song Yilan Zeng Weijin Huang Jinhua Wu Rong Xu Peiwen Luo Xiaofang Yang Xiaodong Zhang Shuangru Luo Ying Liang Xinglin Li Jiaju Huang Qiang Wang Xueqin Huang Qingsong Xu Mei Luo Anliang Huang Dongxia Luo Chenyan Zhao Fan Yang Jian-Bao Han Yong-Tang Zheng Peng Liang
author_sort	Joshua G. Liang
title	S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
title_short	S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
title_full	S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
title_fullStr	S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
title_full_unstemmed	S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
title_sort	s-trimer, a covid-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61db57e69d5a405e82b86f6070a7345d
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S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

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