Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

Chinese breast cancer patients have not been well represented in clinical sequencing studies. Here the authors analyse the mutational landscape of 1,134 Chinese breast cancer patients, finding actionable targets and a higher prevalence of p53 and Hippo pathway mutations compared to Western cohorts.

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Autores principales: Guan-Tian Lang, Yi-Zhou Jiang, Jin-Xiu Shi, Fan Yang, Xiao-Guang Li, Yu-Chen Pei, Chen-Hui Zhang, Ding Ma, Yi Xiao, Peng-Chen Hu, Hai Wang, Yun-Song Yang, Lin-Wei Guo, Xun-Xi Lu, Meng-Zhu Xue, Peng Wang, A-Yong Cao, Hong Ling, Zhong-Hua Wang, Ke-Da Yu, Gen-Hong Di, Da-Qiang Li, Yun-Jin Wang, Ying Yu, Le-Ming Shi, Xin Hu, Wei Huang, Zhi-Ming Shao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/61dd0a122435489e99726b2dc7d128dc
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spelling oai:doaj.org-article:61dd0a122435489e99726b2dc7d128dc2021-12-02T15:39:11ZCharacterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing10.1038/s41467-020-19342-32041-1723https://doaj.org/article/61dd0a122435489e99726b2dc7d128dc2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19342-3https://doaj.org/toc/2041-1723Chinese breast cancer patients have not been well represented in clinical sequencing studies. Here the authors analyse the mutational landscape of 1,134 Chinese breast cancer patients, finding actionable targets and a higher prevalence of p53 and Hippo pathway mutations compared to Western cohorts.Guan-Tian LangYi-Zhou JiangJin-Xiu ShiFan YangXiao-Guang LiYu-Chen PeiChen-Hui ZhangDing MaYi XiaoPeng-Chen HuHai WangYun-Song YangLin-Wei GuoXun-Xi LuMeng-Zhu XuePeng WangA-Yong CaoHong LingZhong-Hua WangKe-Da YuGen-Hong DiDa-Qiang LiYun-Jin WangYing YuLe-Ming ShiXin HuWei HuangZhi-Ming ShaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Guan-Tian Lang
Yi-Zhou Jiang
Jin-Xiu Shi
Fan Yang
Xiao-Guang Li
Yu-Chen Pei
Chen-Hui Zhang
Ding Ma
Yi Xiao
Peng-Chen Hu
Hai Wang
Yun-Song Yang
Lin-Wei Guo
Xun-Xi Lu
Meng-Zhu Xue
Peng Wang
A-Yong Cao
Hong Ling
Zhong-Hua Wang
Ke-Da Yu
Gen-Hong Di
Da-Qiang Li
Yun-Jin Wang
Ying Yu
Le-Ming Shi
Xin Hu
Wei Huang
Zhi-Ming Shao
Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
description Chinese breast cancer patients have not been well represented in clinical sequencing studies. Here the authors analyse the mutational landscape of 1,134 Chinese breast cancer patients, finding actionable targets and a higher prevalence of p53 and Hippo pathway mutations compared to Western cohorts.
format article
author Guan-Tian Lang
Yi-Zhou Jiang
Jin-Xiu Shi
Fan Yang
Xiao-Guang Li
Yu-Chen Pei
Chen-Hui Zhang
Ding Ma
Yi Xiao
Peng-Chen Hu
Hai Wang
Yun-Song Yang
Lin-Wei Guo
Xun-Xi Lu
Meng-Zhu Xue
Peng Wang
A-Yong Cao
Hong Ling
Zhong-Hua Wang
Ke-Da Yu
Gen-Hong Di
Da-Qiang Li
Yun-Jin Wang
Ying Yu
Le-Ming Shi
Xin Hu
Wei Huang
Zhi-Ming Shao
author_facet Guan-Tian Lang
Yi-Zhou Jiang
Jin-Xiu Shi
Fan Yang
Xiao-Guang Li
Yu-Chen Pei
Chen-Hui Zhang
Ding Ma
Yi Xiao
Peng-Chen Hu
Hai Wang
Yun-Song Yang
Lin-Wei Guo
Xun-Xi Lu
Meng-Zhu Xue
Peng Wang
A-Yong Cao
Hong Ling
Zhong-Hua Wang
Ke-Da Yu
Gen-Hong Di
Da-Qiang Li
Yun-Jin Wang
Ying Yu
Le-Ming Shi
Xin Hu
Wei Huang
Zhi-Ming Shao
author_sort Guan-Tian Lang
title Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
title_short Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
title_full Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
title_fullStr Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
title_full_unstemmed Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
title_sort characterization of the genomic landscape and actionable mutations in chinese breast cancers by clinical sequencing
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/61dd0a122435489e99726b2dc7d128dc
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