New insights of phenolic compounds from optimized fruit extract of Ficus auriculata

Abstract In this study, the extraction conditions extracted maximize amounts of phenolic and bioactive compounds from the fruit extract of Ficus auriculata by using optimized response surface methodology. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH...

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Autores principales:	M. Shahinuzzaman, Parul Akhtar, N. Amin, Yunus Ahmed, Farah Hannan Anuar, H. Misran, Md. Akhtaruzzaman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61de10acc85047f7b127c58e381a47b0
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spelling	oai:doaj.org-article:61de10acc85047f7b127c58e381a47b02021-12-02T17:23:47ZNew insights of phenolic compounds from optimized fruit extract of Ficus auriculata10.1038/s41598-021-91913-w2045-2322https://doaj.org/article/61de10acc85047f7b127c58e381a47b02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91913-whttps://doaj.org/toc/2045-2322Abstract In this study, the extraction conditions extracted maximize amounts of phenolic and bioactive compounds from the fruit extract of Ficus auriculata by using optimized response surface methodology. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH and ABTS as well as reducing power assays on total phenolic content (TPC). For the extraction purpose, the ultrasonic assisted extraction technique was employed. A second-order polynomial model satisfactorily fitted to the experimental findings concerning antioxidant activity (R2 = 0.968, P < 0.0001) and total phenolic content (R2 = 0.961, P < 0.0001), indicating a significant correlation between the experimental and expected value. The highest DPPH radical scavenging activity was achieved 85.20 ± 0.96% at the optimum extraction parameters of 52.5% ethanol (v/v), 40.0 °C temperature, and 22 min extraction time. Alternatively, the highest yield of total phenolic content was found 31.65 ± 0.94 mg GAE/g DF at the optimum extraction conditions. From the LC–ESI–MS profiling of the optimized extract, 18 bioactive compounds were tentatively identified, which may regulate the antioxidant activity of fruits of F. auriculata.M. ShahinuzzamanParul AkhtarN. AminYunus AhmedFarah Hannan AnuarH. MisranMd. AkhtaruzzamanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Shahinuzzaman Parul Akhtar N. Amin Yunus Ahmed Farah Hannan Anuar H. Misran Md. Akhtaruzzaman New insights of phenolic compounds from optimized fruit extract of Ficus auriculata
description	Abstract In this study, the extraction conditions extracted maximize amounts of phenolic and bioactive compounds from the fruit extract of Ficus auriculata by using optimized response surface methodology. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH and ABTS as well as reducing power assays on total phenolic content (TPC). For the extraction purpose, the ultrasonic assisted extraction technique was employed. A second-order polynomial model satisfactorily fitted to the experimental findings concerning antioxidant activity (R2 = 0.968, P < 0.0001) and total phenolic content (R2 = 0.961, P < 0.0001), indicating a significant correlation between the experimental and expected value. The highest DPPH radical scavenging activity was achieved 85.20 ± 0.96% at the optimum extraction parameters of 52.5% ethanol (v/v), 40.0 °C temperature, and 22 min extraction time. Alternatively, the highest yield of total phenolic content was found 31.65 ± 0.94 mg GAE/g DF at the optimum extraction conditions. From the LC–ESI–MS profiling of the optimized extract, 18 bioactive compounds were tentatively identified, which may regulate the antioxidant activity of fruits of F. auriculata.
format	article
author	M. Shahinuzzaman Parul Akhtar N. Amin Yunus Ahmed Farah Hannan Anuar H. Misran Md. Akhtaruzzaman
author_facet	M. Shahinuzzaman Parul Akhtar N. Amin Yunus Ahmed Farah Hannan Anuar H. Misran Md. Akhtaruzzaman
author_sort	M. Shahinuzzaman
title	New insights of phenolic compounds from optimized fruit extract of Ficus auriculata
title_short	New insights of phenolic compounds from optimized fruit extract of Ficus auriculata
title_full	New insights of phenolic compounds from optimized fruit extract of Ficus auriculata
title_fullStr	New insights of phenolic compounds from optimized fruit extract of Ficus auriculata
title_full_unstemmed	New insights of phenolic compounds from optimized fruit extract of Ficus auriculata
title_sort	new insights of phenolic compounds from optimized fruit extract of ficus auriculata
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61de10acc85047f7b127c58e381a47b0
work_keys_str_mv	AT mshahinuzzaman newinsightsofphenoliccompoundsfromoptimizedfruitextractofficusauriculata AT parulakhtar newinsightsofphenoliccompoundsfromoptimizedfruitextractofficusauriculata AT namin newinsightsofphenoliccompoundsfromoptimizedfruitextractofficusauriculata AT yunusahmed newinsightsofphenoliccompoundsfromoptimizedfruitextractofficusauriculata AT farahhannananuar newinsightsofphenoliccompoundsfromoptimizedfruitextractofficusauriculata AT hmisran newinsightsofphenoliccompoundsfromoptimizedfruitextractofficusauriculata AT mdakhtaruzzaman newinsightsofphenoliccompoundsfromoptimizedfruitextractofficusauriculata
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New insights of phenolic compounds from optimized fruit extract of Ficus auriculata

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