PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeut...

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Autores principales: Lin Wang, Yilong Zhou, Zijuan Chen, Lei Sun, Juehui Wu, Haohao Li, Feng Liu, Fei Wang, Chunfu Yang, Juhao Yang, Qibin Leng, Qingli Zhang, Ajing Xu, Lisong Shen, Jinqiao Sun, Dianqing Wu, Caiyun Fang, Haojie Lu, Dapeng Yan, Baoxue Ge
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/61df262c7ea34473b596a6f97d705c8e
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spelling oai:doaj.org-article:61df262c7ea34473b596a6f97d705c8e2021-12-02T16:58:26ZPLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK110.1038/s41467-019-08524-32041-1723https://doaj.org/article/61df262c7ea34473b596a6f97d705c8e2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08524-3https://doaj.org/toc/2041-1723Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeutic target.Lin WangYilong ZhouZijuan ChenLei SunJuehui WuHaohao LiFeng LiuFei WangChunfu YangJuhao YangQibin LengQingli ZhangAjing XuLisong ShenJinqiao SunDianqing WuCaiyun FangHaojie LuDapeng YanBaoxue GeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lin Wang
Yilong Zhou
Zijuan Chen
Lei Sun
Juehui Wu
Haohao Li
Feng Liu
Fei Wang
Chunfu Yang
Juhao Yang
Qibin Leng
Qingli Zhang
Ajing Xu
Lisong Shen
Jinqiao Sun
Dianqing Wu
Caiyun Fang
Haojie Lu
Dapeng Yan
Baoxue Ge
PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
description Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeutic target.
format article
author Lin Wang
Yilong Zhou
Zijuan Chen
Lei Sun
Juehui Wu
Haohao Li
Feng Liu
Fei Wang
Chunfu Yang
Juhao Yang
Qibin Leng
Qingli Zhang
Ajing Xu
Lisong Shen
Jinqiao Sun
Dianqing Wu
Caiyun Fang
Haojie Lu
Dapeng Yan
Baoxue Ge
author_facet Lin Wang
Yilong Zhou
Zijuan Chen
Lei Sun
Juehui Wu
Haohao Li
Feng Liu
Fei Wang
Chunfu Yang
Juhao Yang
Qibin Leng
Qingli Zhang
Ajing Xu
Lisong Shen
Jinqiao Sun
Dianqing Wu
Caiyun Fang
Haojie Lu
Dapeng Yan
Baoxue Ge
author_sort Lin Wang
title PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
title_short PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
title_full PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
title_fullStr PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
title_full_unstemmed PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
title_sort plcβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of tak1
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/61df262c7ea34473b596a6f97d705c8e
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