Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that Ca2+ is a required cofactor for Fpn transport act...

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Autores principales:	Chandrika N. Deshpande, T. Alex Ruwe, Ali Shawki, Vicky Xin, Kyle R. Vieth, Erika V. Valore, Bo Qiao, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61dff6b0396e40ccba89522883e761ae
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spelling	oai:doaj.org-article:61dff6b0396e40ccba89522883e761ae2021-12-02T14:39:09ZCalcium is an essential cofactor for metal efflux by the ferroportin transporter family10.1038/s41467-018-05446-42041-1723https://doaj.org/article/61dff6b0396e40ccba89522883e761ae2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05446-4https://doaj.org/toc/2041-1723Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that Ca2+ is a required cofactor for Fpn transport activity.Chandrika N. DeshpandeT. Alex RuweAli ShawkiVicky XinKyle R. ViethErika V. ValoreBo QiaoTomas GanzElizabeta NemethBryan MackenzieMika JormakkaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chandrika N. Deshpande T. Alex Ruwe Ali Shawki Vicky Xin Kyle R. Vieth Erika V. Valore Bo Qiao Tomas Ganz Elizabeta Nemeth Bryan Mackenzie Mika Jormakka Calcium is an essential cofactor for metal efflux by the ferroportin transporter family
description	Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that Ca2+ is a required cofactor for Fpn transport activity.
format	article
author	Chandrika N. Deshpande T. Alex Ruwe Ali Shawki Vicky Xin Kyle R. Vieth Erika V. Valore Bo Qiao Tomas Ganz Elizabeta Nemeth Bryan Mackenzie Mika Jormakka
author_facet	Chandrika N. Deshpande T. Alex Ruwe Ali Shawki Vicky Xin Kyle R. Vieth Erika V. Valore Bo Qiao Tomas Ganz Elizabeta Nemeth Bryan Mackenzie Mika Jormakka
author_sort	Chandrika N. Deshpande
title	Calcium is an essential cofactor for metal efflux by the ferroportin transporter family
title_short	Calcium is an essential cofactor for metal efflux by the ferroportin transporter family
title_full	Calcium is an essential cofactor for metal efflux by the ferroportin transporter family
title_fullStr	Calcium is an essential cofactor for metal efflux by the ferroportin transporter family
title_full_unstemmed	Calcium is an essential cofactor for metal efflux by the ferroportin transporter family
title_sort	calcium is an essential cofactor for metal efflux by the ferroportin transporter family
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/61dff6b0396e40ccba89522883e761ae
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Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

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