The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy

Aim. To study effect of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells (CPC) in patients with coronary heart disease(CHD) and postinfarction heart failure (ischemic cardiomyopathy).Methods. The number of CPC (CD34+ cells) was determined by flow cytophotometry in...

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Autores principales: Tatiana Nikolaevna Kochegura, Zhanna Alekseevna Akopyan, Georgy Vladimirovich Sharonov, Anastasia Yur'evna Efimenko, Fail' Taipovich Ageev, Artem Germanovich Ovchinnikov, Lyudmila Vital'evna Zhigunova, Elena Leonidovna Lakhova, Boris Dmitrievich Kulev, Angelina Vladimirovna Sokolova, Marina Vladimirovna Shestakova, Elena Viktorovna Parfenova
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RU
Publicado: Endocrinology Research Centre 2011
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spelling oai:doaj.org-article:61e853b4c0c6425c8277f219f4e3a2b62021-11-14T09:00:16ZThe influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy2072-03512072-037810.14341/2072-0351-6222https://doaj.org/article/61e853b4c0c6425c8277f219f4e3a2b62011-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6222https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study effect of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells (CPC) in patients with coronary heart disease(CHD) and postinfarction heart failure (ischemic cardiomyopathy).Methods. The number of CPC (CD34+ cells) was determined by flow cytophotometry in 47 patients with CHD including 14 with CHD + DM2; 12patients without CHD and DM2 made up the control grouP. Enzyme-linked immunosorbent assay was used to measure N-terminal precursor of brainnatriuretic peptide (NT-proBNP), immunoreactive insulin (IRI) and C-peptide levels. Results. The number of CPC in patients with ischemic cardiomyopathy without DM2 was 33.4% greater than in controls. In patients with cardiomyopathyand DM2 the number of CPC depended on the quality of diabetes compensation. It was lowest in case of decompensated DM2 (HbA1c=9.5?1.8%).In patients with compensated/subcompensated DM2 (HbA1c=6.8?0.3%) it was significantly higher than in controls and patients with ischemiccardiomyopathy without DM2 (mean 46.5 (p=0.006) and 40.0% (p=0.02) respectively). Conclusion. The number of CPC in peripheral blood of patients with ischemic cardiomyopathy and DM2 correlated with the level of DM compensation.It was lowest in patients with decompensated DM2 and exceeded the normal number in patients with CHD without DM2. The number of CPC inverselycorrelated with blood glucose level. Positive correlation of CPC number with IRI and C-peptide levels was documented in control subjects and patientswith CHD without DM2.Tatiana Nikolaevna KocheguraZhanna Alekseevna AkopyanGeorgy Vladimirovich SharonovAnastasia Yur'evna EfimenkoFail' Taipovich AgeevArtem Germanovich OvchinnikovLyudmila Vital'evna ZhigunovaElena Leonidovna LakhovaBoris Dmitrievich KulevAngelina Vladimirovna SokolovaMarina Vladimirovna ShestakovaElena Viktorovna ParfenovaEndocrinology Research Centrearticlecirculating progenitor cellstype 2 diabetescoronary heart diseaseNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 3, Pp 36-43 (2011)
institution DOAJ
collection DOAJ
language EN
RU
topic circulating progenitor cells
type 2 diabetes
coronary heart disease
Nutritional diseases. Deficiency diseases
RC620-627
spellingShingle circulating progenitor cells
type 2 diabetes
coronary heart disease
Nutritional diseases. Deficiency diseases
RC620-627
Tatiana Nikolaevna Kochegura
Zhanna Alekseevna Akopyan
Georgy Vladimirovich Sharonov
Anastasia Yur'evna Efimenko
Fail' Taipovich Ageev
Artem Germanovich Ovchinnikov
Lyudmila Vital'evna Zhigunova
Elena Leonidovna Lakhova
Boris Dmitrievich Kulev
Angelina Vladimirovna Sokolova
Marina Vladimirovna Shestakova
Elena Viktorovna Parfenova
The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
description Aim. To study effect of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells (CPC) in patients with coronary heart disease(CHD) and postinfarction heart failure (ischemic cardiomyopathy).Methods. The number of CPC (CD34+ cells) was determined by flow cytophotometry in 47 patients with CHD including 14 with CHD + DM2; 12patients without CHD and DM2 made up the control grouP. Enzyme-linked immunosorbent assay was used to measure N-terminal precursor of brainnatriuretic peptide (NT-proBNP), immunoreactive insulin (IRI) and C-peptide levels. Results. The number of CPC in patients with ischemic cardiomyopathy without DM2 was 33.4% greater than in controls. In patients with cardiomyopathyand DM2 the number of CPC depended on the quality of diabetes compensation. It was lowest in case of decompensated DM2 (HbA1c=9.5?1.8%).In patients with compensated/subcompensated DM2 (HbA1c=6.8?0.3%) it was significantly higher than in controls and patients with ischemiccardiomyopathy without DM2 (mean 46.5 (p=0.006) and 40.0% (p=0.02) respectively). Conclusion. The number of CPC in peripheral blood of patients with ischemic cardiomyopathy and DM2 correlated with the level of DM compensation.It was lowest in patients with decompensated DM2 and exceeded the normal number in patients with CHD without DM2. The number of CPC inverselycorrelated with blood glucose level. Positive correlation of CPC number with IRI and C-peptide levels was documented in control subjects and patientswith CHD without DM2.
format article
author Tatiana Nikolaevna Kochegura
Zhanna Alekseevna Akopyan
Georgy Vladimirovich Sharonov
Anastasia Yur'evna Efimenko
Fail' Taipovich Ageev
Artem Germanovich Ovchinnikov
Lyudmila Vital'evna Zhigunova
Elena Leonidovna Lakhova
Boris Dmitrievich Kulev
Angelina Vladimirovna Sokolova
Marina Vladimirovna Shestakova
Elena Viktorovna Parfenova
author_facet Tatiana Nikolaevna Kochegura
Zhanna Alekseevna Akopyan
Georgy Vladimirovich Sharonov
Anastasia Yur'evna Efimenko
Fail' Taipovich Ageev
Artem Germanovich Ovchinnikov
Lyudmila Vital'evna Zhigunova
Elena Leonidovna Lakhova
Boris Dmitrievich Kulev
Angelina Vladimirovna Sokolova
Marina Vladimirovna Shestakova
Elena Viktorovna Parfenova
author_sort Tatiana Nikolaevna Kochegura
title The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
title_short The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
title_full The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
title_fullStr The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
title_full_unstemmed The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
title_sort influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
publisher Endocrinology Research Centre
publishDate 2011
url https://doaj.org/article/61e853b4c0c6425c8277f219f4e3a2b6
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