SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.

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Autores principales:	Xiaolong Tang, Lei Shi, Ni Xie, Zuojun Liu, Minxian Qian, Fanbiao Meng, Qingyang Xu, Mingyan Zhou, Xinyue Cao, Wei-Guo Zhu, Baohua Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61edb8082aef41148c0c2751a9ef0fe7
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spelling	oai:doaj.org-article:61edb8082aef41148c0c2751a9ef0fe72021-12-02T13:57:54ZSIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis10.1038/s41467-017-00396-92041-1723https://doaj.org/article/61edb8082aef41148c0c2751a9ef0fe72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00396-9https://doaj.org/toc/2041-1723Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.Xiaolong TangLei ShiNi XieZuojun LiuMinxian QianFanbiao MengQingyang XuMingyan ZhouXinyue CaoWei-Guo ZhuBaohua LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaolong Tang Lei Shi Ni Xie Zuojun Liu Minxian Qian Fanbiao Meng Qingyang Xu Mingyan Zhou Xinyue Cao Wei-Guo Zhu Baohua Liu SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis
description	Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.
format	article
author	Xiaolong Tang Lei Shi Ni Xie Zuojun Liu Minxian Qian Fanbiao Meng Qingyang Xu Mingyan Zhou Xinyue Cao Wei-Guo Zhu Baohua Liu
author_facet	Xiaolong Tang Lei Shi Ni Xie Zuojun Liu Minxian Qian Fanbiao Meng Qingyang Xu Mingyan Zhou Xinyue Cao Wei-Guo Zhu Baohua Liu
author_sort	Xiaolong Tang
title	SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis
title_short	SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis
title_full	SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis
title_fullStr	SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis
title_full_unstemmed	SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis
title_sort	sirt7 antagonizes tgf-β signaling and inhibits breast cancer metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/61edb8082aef41148c0c2751a9ef0fe7
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SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

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