SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.

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Autores principales: Xiaolong Tang, Lei Shi, Ni Xie, Zuojun Liu, Minxian Qian, Fanbiao Meng, Qingyang Xu, Mingyan Zhou, Xinyue Cao, Wei-Guo Zhu, Baohua Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/61edb8082aef41148c0c2751a9ef0fe7
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