Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

Multi-omic profiling is a powerful approach to dissecting molecular mechanisms in disease. Here the authors generate whole proteome, phosphoproteome and transcriptome profiles from two mouse models of high-grade glioma driven by different oncogenes, and validate identified master regulators with a C...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hong Wang, Alexander K. Diaz, Timothy I. Shaw, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Barbara S. Paugh, Yang Zhang, Jeffrey Sifford, Bing Bai, Zhiping Wu, Haiyan Tan, Suiping Zhou, Laura D. Hover, Heather S. Tillman, Abbas Shirinifard, Suresh Thiagarajan, Andras Sablauer, Vishwajeeth Pagala, Anthony A. High, Xusheng Wang, Chunliang Li, Suzanne J. Baker, Junmin Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61f32b7ce86246f7a09c004f13127043
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:61f32b7ce86246f7a09c004f13127043
record_format	dspace
spelling	oai:doaj.org-article:61f32b7ce86246f7a09c004f131270432021-12-02T17:01:52ZDeep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes10.1038/s41467-019-11661-42041-1723https://doaj.org/article/61f32b7ce86246f7a09c004f131270432019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11661-4https://doaj.org/toc/2041-1723Multi-omic profiling is a powerful approach to dissecting molecular mechanisms in disease. Here the authors generate whole proteome, phosphoproteome and transcriptome profiles from two mouse models of high-grade glioma driven by different oncogenes, and validate identified master regulators with a CRISPR screen.Hong WangAlexander K. DiazTimothy I. ShawYuxin LiMingming NiuJi-Hoon ChoBarbara S. PaughYang ZhangJeffrey SiffordBing BaiZhiping WuHaiyan TanSuiping ZhouLaura D. HoverHeather S. TillmanAbbas ShirinifardSuresh ThiagarajanAndras SablauerVishwajeeth PagalaAnthony A. HighXusheng WangChunliang LiSuzanne J. BakerJunmin PengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong Wang Alexander K. Diaz Timothy I. Shaw Yuxin Li Mingming Niu Ji-Hoon Cho Barbara S. Paugh Yang Zhang Jeffrey Sifford Bing Bai Zhiping Wu Haiyan Tan Suiping Zhou Laura D. Hover Heather S. Tillman Abbas Shirinifard Suresh Thiagarajan Andras Sablauer Vishwajeeth Pagala Anthony A. High Xusheng Wang Chunliang Li Suzanne J. Baker Junmin Peng Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
description	Multi-omic profiling is a powerful approach to dissecting molecular mechanisms in disease. Here the authors generate whole proteome, phosphoproteome and transcriptome profiles from two mouse models of high-grade glioma driven by different oncogenes, and validate identified master regulators with a CRISPR screen.
format	article
author	Hong Wang Alexander K. Diaz Timothy I. Shaw Yuxin Li Mingming Niu Ji-Hoon Cho Barbara S. Paugh Yang Zhang Jeffrey Sifford Bing Bai Zhiping Wu Haiyan Tan Suiping Zhou Laura D. Hover Heather S. Tillman Abbas Shirinifard Suresh Thiagarajan Andras Sablauer Vishwajeeth Pagala Anthony A. High Xusheng Wang Chunliang Li Suzanne J. Baker Junmin Peng
author_facet	Hong Wang Alexander K. Diaz Timothy I. Shaw Yuxin Li Mingming Niu Ji-Hoon Cho Barbara S. Paugh Yang Zhang Jeffrey Sifford Bing Bai Zhiping Wu Haiyan Tan Suiping Zhou Laura D. Hover Heather S. Tillman Abbas Shirinifard Suresh Thiagarajan Andras Sablauer Vishwajeeth Pagala Anthony A. High Xusheng Wang Chunliang Li Suzanne J. Baker Junmin Peng
author_sort	Hong Wang
title	Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
title_short	Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
title_full	Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
title_fullStr	Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
title_full_unstemmed	Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
title_sort	deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/61f32b7ce86246f7a09c004f13127043
work_keys_str_mv	AT hongwang deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT alexanderkdiaz deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT timothyishaw deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT yuxinli deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT mingmingniu deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT jihooncho deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT barbaraspaugh deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT yangzhang deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT jeffreysifford deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT bingbai deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT zhipingwu deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT haiyantan deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT suipingzhou deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT lauradhover deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT heatherstillman deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT abbasshirinifard deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT sureshthiagarajan deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT andrassablauer deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT vishwajeethpagala deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT anthonyahigh deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT xushengwang deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT chunliangli deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT suzannejbaker deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes AT junminpeng deepmultiomicsprofilingofbraintumorsidentifiessignalingnetworksdownstreamofcancerdrivergenes
_version_	1718382031586459648

Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

Ejemplares similares