The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study
Abstract Recently, covering materials for protecting post-endoscopic ulcers are being developed using hydrogels. Existing hydrogels are not ideal coating materials because it is difficult to control their physical properties. Therefore, we conducted an animal pilot study to investigate the protectiv...
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Nature Portfolio
2021
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oai:doaj.org-article:61f4861ba4e048bc962c7c09d0de2aaf2021-12-02T18:50:52ZThe feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study10.1038/s41598-021-97988-92045-2322https://doaj.org/article/61f4861ba4e048bc962c7c09d0de2aaf2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97988-9https://doaj.org/toc/2045-2322Abstract Recently, covering materials for protecting post-endoscopic ulcers are being developed using hydrogels. Existing hydrogels are not ideal coating materials because it is difficult to control their physical properties. Therefore, we conducted an animal pilot study to investigate the protective effect of a novel ulcer coating material, whose physical properties can be easily controlled and designed. We applied the novel injectable hydrogel to artificial ulcers induced on the gastric mucosa of rats. Rats were assigned to the hydrogel or the control group. To measure the protective effect of hydrogel on ulcers, the perforation rate, ulcer diameter, and ulcer area were evaluated 48 h after gel application. As secondary endpoints, we assessed the residual rate of the hydrogel at the bottom of the ulcer, performed histological analysis, and analyzed adverse events associated with hydrogel. The perforation rate was significantly lower (16% vs. 75%) and the mean diameter of ulcers was significantly smaller (5.4 ± 1.8 mm vs. 7.8 ± 2.8 mm) in the hydrogel group. Histopathological findings revealed the inflammatory cell count was significantly higher in the control group. Our novel hydrogel showed a protective effect on artificial gastric ulcers in a rat model.Yuko MiuraYosuke TsujiRina ChoAyano FujisawaMasahiko FujisawaHiroyuki KamataYuki YoshikawaNobutake YamamichiTakamasa SakaiKazuhiko KoikeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
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Medicine R Science Q Yuko Miura Yosuke Tsuji Rina Cho Ayano Fujisawa Masahiko Fujisawa Hiroyuki Kamata Yuki Yoshikawa Nobutake Yamamichi Takamasa Sakai Kazuhiko Koike The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study |
| description |
Abstract Recently, covering materials for protecting post-endoscopic ulcers are being developed using hydrogels. Existing hydrogels are not ideal coating materials because it is difficult to control their physical properties. Therefore, we conducted an animal pilot study to investigate the protective effect of a novel ulcer coating material, whose physical properties can be easily controlled and designed. We applied the novel injectable hydrogel to artificial ulcers induced on the gastric mucosa of rats. Rats were assigned to the hydrogel or the control group. To measure the protective effect of hydrogel on ulcers, the perforation rate, ulcer diameter, and ulcer area were evaluated 48 h after gel application. As secondary endpoints, we assessed the residual rate of the hydrogel at the bottom of the ulcer, performed histological analysis, and analyzed adverse events associated with hydrogel. The perforation rate was significantly lower (16% vs. 75%) and the mean diameter of ulcers was significantly smaller (5.4 ± 1.8 mm vs. 7.8 ± 2.8 mm) in the hydrogel group. Histopathological findings revealed the inflammatory cell count was significantly higher in the control group. Our novel hydrogel showed a protective effect on artificial gastric ulcers in a rat model. |
| format |
article |
| author |
Yuko Miura Yosuke Tsuji Rina Cho Ayano Fujisawa Masahiko Fujisawa Hiroyuki Kamata Yuki Yoshikawa Nobutake Yamamichi Takamasa Sakai Kazuhiko Koike |
| author_facet |
Yuko Miura Yosuke Tsuji Rina Cho Ayano Fujisawa Masahiko Fujisawa Hiroyuki Kamata Yuki Yoshikawa Nobutake Yamamichi Takamasa Sakai Kazuhiko Koike |
| author_sort |
Yuko Miura |
| title |
The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study |
| title_short |
The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study |
| title_full |
The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study |
| title_fullStr |
The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study |
| title_full_unstemmed |
The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study |
| title_sort |
feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/61f4861ba4e048bc962c7c09d0de2aaf |
| work_keys_str_mv |
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