Engineering advanced logic and distributed computing in human CAR immune cells

Most CAR designs lack control and computation features, limiting the sophistication of the engineered immune response. Here the authors leverage a split CAR design for engineering coordinated immune responses.

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Detalles Bibliográficos
Autores principales: Jang Hwan Cho, Atsushi Okuma, Katri Sofjan, Seunghee Lee, James J. Collins, Wilson W. Wong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
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Acceso en línea:https://doaj.org/article/61f573b3bec2461cb3c23455806f7d6a
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Descripción
Sumario:Most CAR designs lack control and computation features, limiting the sophistication of the engineered immune response. Here the authors leverage a split CAR design for engineering coordinated immune responses.