Engineering advanced logic and distributed computing in human CAR immune cells

Most CAR designs lack control and computation features, limiting the sophistication of the engineered immune response. Here the authors leverage a split CAR design for engineering coordinated immune responses.

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Autores principales:	Jang Hwan Cho, Atsushi Okuma, Katri Sofjan, Seunghee Lee, James J. Collins, Wilson W. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61f573b3bec2461cb3c23455806f7d6a
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spelling	oai:doaj.org-article:61f573b3bec2461cb3c23455806f7d6a2021-12-02T14:06:09ZEngineering advanced logic and distributed computing in human CAR immune cells10.1038/s41467-021-21078-72041-1723https://doaj.org/article/61f573b3bec2461cb3c23455806f7d6a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21078-7https://doaj.org/toc/2041-1723Most CAR designs lack control and computation features, limiting the sophistication of the engineered immune response. Here the authors leverage a split CAR design for engineering coordinated immune responses.Jang Hwan ChoAtsushi OkumaKatri SofjanSeunghee LeeJames J. CollinsWilson W. WongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jang Hwan Cho Atsushi Okuma Katri Sofjan Seunghee Lee James J. Collins Wilson W. Wong Engineering advanced logic and distributed computing in human CAR immune cells
description	Most CAR designs lack control and computation features, limiting the sophistication of the engineered immune response. Here the authors leverage a split CAR design for engineering coordinated immune responses.
format	article
author	Jang Hwan Cho Atsushi Okuma Katri Sofjan Seunghee Lee James J. Collins Wilson W. Wong
author_facet	Jang Hwan Cho Atsushi Okuma Katri Sofjan Seunghee Lee James J. Collins Wilson W. Wong
author_sort	Jang Hwan Cho
title	Engineering advanced logic and distributed computing in human CAR immune cells
title_short	Engineering advanced logic and distributed computing in human CAR immune cells
title_full	Engineering advanced logic and distributed computing in human CAR immune cells
title_fullStr	Engineering advanced logic and distributed computing in human CAR immune cells
title_full_unstemmed	Engineering advanced logic and distributed computing in human CAR immune cells
title_sort	engineering advanced logic and distributed computing in human car immune cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61f573b3bec2461cb3c23455806f7d6a
work_keys_str_mv	AT janghwancho engineeringadvancedlogicanddistributedcomputinginhumancarimmunecells AT atsushiokuma engineeringadvancedlogicanddistributedcomputinginhumancarimmunecells AT katrisofjan engineeringadvancedlogicanddistributedcomputinginhumancarimmunecells AT seungheelee engineeringadvancedlogicanddistributedcomputinginhumancarimmunecells AT jamesjcollins engineeringadvancedlogicanddistributedcomputinginhumancarimmunecells AT wilsonwwong engineeringadvancedlogicanddistributedcomputinginhumancarimmunecells
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Engineering advanced logic and distributed computing in human CAR immune cells

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