MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Abstract Background MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularly as signaling molecules. The identity of miRNA sp...

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Détails bibliographiques
Auteurs principaux: Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik, Rolf Backofen, Patrick Scheerer, Seija Lehnardt
Format: article
Langue:EN
Publié: BMC 2021
Sujets:
Extracellular microRNAs
Endogenous Toll-like receptor ligands
Cortical neurons
Neuronal apoptosis
Microglia
Neurodegeneration
Neurology. Diseases of the nervous system
RC346-429
Geriatrics
RC952-954.6
Accès en ligne:https://doaj.org/article/61f971538f07412cba14e312e4335927
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https://doaj.org/article/61f971538f07412cba14e312e4335927

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