Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Vascular senescence is closely associated with individual ageing, while its causative role remains unclear. Here Barinda et al. generate endothelial cell-specific progeroind mice, and reveal that endothelial cell senescence directly induces metabolic disorders through senescence-messaging secretomes...

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Autores principales:	Agian Jeffilano Barinda, Koji Ikeda, Dhite Bayu Nugroho, Donytra Arby Wardhana, Naoto Sasaki, Sakiko Honda, Ryota Urata, Satoaki Matoba, Ken-ichi Hirata, Noriaki Emoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61fe8af3c742422ab12a8bd197abc57b
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spelling	oai:doaj.org-article:61fe8af3c742422ab12a8bd197abc57b2021-12-02T15:39:28ZEndothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype10.1038/s41467-020-14387-w2041-1723https://doaj.org/article/61fe8af3c742422ab12a8bd197abc57b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14387-whttps://doaj.org/toc/2041-1723Vascular senescence is closely associated with individual ageing, while its causative role remains unclear. Here Barinda et al. generate endothelial cell-specific progeroind mice, and reveal that endothelial cell senescence directly induces metabolic disorders through senescence-messaging secretomes.Agian Jeffilano BarindaKoji IkedaDhite Bayu NugrohoDonytra Arby WardhanaNaoto SasakiSakiko HondaRyota UrataSatoaki MatobaKen-ichi HirataNoriaki EmotoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Agian Jeffilano Barinda Koji Ikeda Dhite Bayu Nugroho Donytra Arby Wardhana Naoto Sasaki Sakiko Honda Ryota Urata Satoaki Matoba Ken-ichi Hirata Noriaki Emoto Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
description	Vascular senescence is closely associated with individual ageing, while its causative role remains unclear. Here Barinda et al. generate endothelial cell-specific progeroind mice, and reveal that endothelial cell senescence directly induces metabolic disorders through senescence-messaging secretomes.
format	article
author	Agian Jeffilano Barinda Koji Ikeda Dhite Bayu Nugroho Donytra Arby Wardhana Naoto Sasaki Sakiko Honda Ryota Urata Satoaki Matoba Ken-ichi Hirata Noriaki Emoto
author_facet	Agian Jeffilano Barinda Koji Ikeda Dhite Bayu Nugroho Donytra Arby Wardhana Naoto Sasaki Sakiko Honda Ryota Urata Satoaki Matoba Ken-ichi Hirata Noriaki Emoto
author_sort	Agian Jeffilano Barinda
title	Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
title_short	Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
title_full	Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
title_fullStr	Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
title_full_unstemmed	Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
title_sort	endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/61fe8af3c742422ab12a8bd197abc57b
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Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

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