The Role of HGF/MET Signaling in Metastatic Uveal Melanoma

Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling promotes tumorigenesis and tumor progression in various types of cancer, including uveal melanoma (UM). The roles of HGF/MET signaling have been studied in cell survival, proliferation, cell motility, and migrati...

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Autores principales:	Ryota Tanaka, Mizue Terai, Eric Londin, Takami Sato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocyte growth factor (HGF) mesenchymal-epithelial transition factor (MET) uveal melanoma metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6201554d294145c1a447b4a4b4fe1ca2
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id	oai:doaj.org-article:6201554d294145c1a447b4a4b4fe1ca2
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spelling	oai:doaj.org-article:6201554d294145c1a447b4a4b4fe1ca22021-11-11T15:33:30ZThe Role of HGF/MET Signaling in Metastatic Uveal Melanoma10.3390/cancers132154572072-6694https://doaj.org/article/6201554d294145c1a447b4a4b4fe1ca22021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5457https://doaj.org/toc/2072-6694Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling promotes tumorigenesis and tumor progression in various types of cancer, including uveal melanoma (UM). The roles of HGF/MET signaling have been studied in cell survival, proliferation, cell motility, and migration. Furthermore, HGF/MET signaling has emerged as a critical player not only in the tumor itself but also in the tumor microenvironment. Expression of MET is frequently observed in metastatic uveal melanoma and is associated with poor prognosis. It has been reported that HGF/MET signaling pathway activation is the major mechanism of treatment resistance in metastatic UM (MUM). To achieve maximal therapeutic benefit in MUM patients, it is important to understand how MET signaling drives cellular functions in uveal melanoma cells. Here, we review the HGF/MET signaling biology and the role of HGF/MET blockades in uveal melanoma.Ryota TanakaMizue TeraiEric LondinTakami SatoMDPI AGarticlehepatocyte growth factor (HGF)mesenchymal-epithelial transition factor (MET)uveal melanomametastasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5457, p 5457 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocyte growth factor (HGF) mesenchymal-epithelial transition factor (MET) uveal melanoma metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocyte growth factor (HGF) mesenchymal-epithelial transition factor (MET) uveal melanoma metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ryota Tanaka Mizue Terai Eric Londin Takami Sato The Role of HGF/MET Signaling in Metastatic Uveal Melanoma
description	Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling promotes tumorigenesis and tumor progression in various types of cancer, including uveal melanoma (UM). The roles of HGF/MET signaling have been studied in cell survival, proliferation, cell motility, and migration. Furthermore, HGF/MET signaling has emerged as a critical player not only in the tumor itself but also in the tumor microenvironment. Expression of MET is frequently observed in metastatic uveal melanoma and is associated with poor prognosis. It has been reported that HGF/MET signaling pathway activation is the major mechanism of treatment resistance in metastatic UM (MUM). To achieve maximal therapeutic benefit in MUM patients, it is important to understand how MET signaling drives cellular functions in uveal melanoma cells. Here, we review the HGF/MET signaling biology and the role of HGF/MET blockades in uveal melanoma.
format	article
author	Ryota Tanaka Mizue Terai Eric Londin Takami Sato
author_facet	Ryota Tanaka Mizue Terai Eric Londin Takami Sato
author_sort	Ryota Tanaka
title	The Role of HGF/MET Signaling in Metastatic Uveal Melanoma
title_short	The Role of HGF/MET Signaling in Metastatic Uveal Melanoma
title_full	The Role of HGF/MET Signaling in Metastatic Uveal Melanoma
title_fullStr	The Role of HGF/MET Signaling in Metastatic Uveal Melanoma
title_full_unstemmed	The Role of HGF/MET Signaling in Metastatic Uveal Melanoma
title_sort	role of hgf/met signaling in metastatic uveal melanoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6201554d294145c1a447b4a4b4fe1ca2
work_keys_str_mv	AT ryotatanaka theroleofhgfmetsignalinginmetastaticuvealmelanoma AT mizueterai theroleofhgfmetsignalinginmetastaticuvealmelanoma AT ericlondin theroleofhgfmetsignalinginmetastaticuvealmelanoma AT takamisato theroleofhgfmetsignalinginmetastaticuvealmelanoma AT ryotatanaka roleofhgfmetsignalinginmetastaticuvealmelanoma AT mizueterai roleofhgfmetsignalinginmetastaticuvealmelanoma AT ericlondin roleofhgfmetsignalinginmetastaticuvealmelanoma AT takamisato roleofhgfmetsignalinginmetastaticuvealmelanoma
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The Role of HGF/MET Signaling in Metastatic Uveal Melanoma

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