Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides

The catalytic C(sp3)-CF2 bond formation is of high interest in drug design and discovery. Here, the authors report a cobalt-catalyzed difluoroalkylation of tertiary α-C-H bonds of aryl ketones for facile synthesis of quaternary alkyl difluorides and show the late-stage functionalization of marketed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chao Li, Yi-Xuan Cao, Rui Wang, Yi-Ning Wang, Quan Lan, Xi-Sheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62021ea85c0c4f93964dc4bb2200c560
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62021ea85c0c4f93964dc4bb2200c560
record_format	dspace
spelling	oai:doaj.org-article:62021ea85c0c4f93964dc4bb2200c5602021-12-02T17:32:17ZCobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides10.1038/s41467-018-07525-y2041-1723https://doaj.org/article/62021ea85c0c4f93964dc4bb2200c5602018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07525-yhttps://doaj.org/toc/2041-1723The catalytic C(sp3)-CF2 bond formation is of high interest in drug design and discovery. Here, the authors report a cobalt-catalyzed difluoroalkylation of tertiary α-C-H bonds of aryl ketones for facile synthesis of quaternary alkyl difluorides and show the late-stage functionalization of marketed drugs.Chao LiYi-Xuan CaoRui WangYi-Ning WangQuan LanXi-Sheng WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Li Yi-Xuan Cao Rui Wang Yi-Ning Wang Quan Lan Xi-Sheng Wang Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
description	The catalytic C(sp3)-CF2 bond formation is of high interest in drug design and discovery. Here, the authors report a cobalt-catalyzed difluoroalkylation of tertiary α-C-H bonds of aryl ketones for facile synthesis of quaternary alkyl difluorides and show the late-stage functionalization of marketed drugs.
format	article
author	Chao Li Yi-Xuan Cao Rui Wang Yi-Ning Wang Quan Lan Xi-Sheng Wang
author_facet	Chao Li Yi-Xuan Cao Rui Wang Yi-Ning Wang Quan Lan Xi-Sheng Wang
author_sort	Chao Li
title	Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
title_short	Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
title_full	Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
title_fullStr	Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
title_full_unstemmed	Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
title_sort	cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/62021ea85c0c4f93964dc4bb2200c560
work_keys_str_mv	AT chaoli cobaltcatalyzeddifluoroalkylationoftertiaryarylketonesforfacilesynthesisofquaternaryalkyldifluorides AT yixuancao cobaltcatalyzeddifluoroalkylationoftertiaryarylketonesforfacilesynthesisofquaternaryalkyldifluorides AT ruiwang cobaltcatalyzeddifluoroalkylationoftertiaryarylketonesforfacilesynthesisofquaternaryalkyldifluorides AT yiningwang cobaltcatalyzeddifluoroalkylationoftertiaryarylketonesforfacilesynthesisofquaternaryalkyldifluorides AT quanlan cobaltcatalyzeddifluoroalkylationoftertiaryarylketonesforfacilesynthesisofquaternaryalkyldifluorides AT xishengwang cobaltcatalyzeddifluoroalkylationoftertiaryarylketonesforfacilesynthesisofquaternaryalkyldifluorides
_version_	1718380312765923328

Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides

Ejemplares similares