Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.

Inflammatory disorders of the central nervous system such as multiple sclerosis and acute disseminated encephalomyelitis involve an invasion of immune cells that ultimately leads to white matter demyelination, neurodegeneration and development of neurological symptoms. A clinical diagnosis is often...

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Autores principales:	Stefano Lepore, Helmar Waiczies, Jan Hentschel, Yiyi Ji, Julia Skodowski, Andreas Pohlmann, Jason M Millward, Friedemann Paul, Jens Wuerfel, Thoralf Niendorf, Sonia Waiczies
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/620621b02c554a37817544c4df20a70b
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spelling	oai:doaj.org-article:620621b02c554a37817544c4df20a70b2021-11-18T08:58:25ZEnlargement of cerebral ventricles as an early indicator of encephalomyelitis.1932-620310.1371/journal.pone.0072841https://doaj.org/article/620621b02c554a37817544c4df20a70b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991157/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Inflammatory disorders of the central nervous system such as multiple sclerosis and acute disseminated encephalomyelitis involve an invasion of immune cells that ultimately leads to white matter demyelination, neurodegeneration and development of neurological symptoms. A clinical diagnosis is often made when neurodegenerative processes are already ongoing. In an attempt to seek early indicators of disease, we studied the temporal and spatial distribution of brain modifications in experimental autoimmune encephalomyelitis (EAE). In a thorough magnetic resonance imaging study performed with EAE mice, we observed significant enlargement of the ventricles prior to disease clinical manifestation and an increase in free water content within the cerebrospinal fluid as demonstrated by changes in T2 relaxation times. The increase in ventricle size was seen in the lateral, third and fourth ventricles. In some EAE mice the ventricle size started returning to normal values during disease remission. In parallel to this macroscopic phenomenon, we studied the temporal evolution of microscopic lesions commonly observed in the cerebellum also starting prior to disease onset. Our data suggest that changes in ventricle size during the early stages of brain inflammation could be an early indicator of the events preceding neurological disease and warrant further exploration in preclinical and clinical studies.Stefano LeporeHelmar WaicziesJan HentschelYiyi JiJulia SkodowskiAndreas PohlmannJason M MillwardFriedemann PaulJens WuerfelThoralf NiendorfSonia WaicziesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e72841 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Lepore Helmar Waiczies Jan Hentschel Yiyi Ji Julia Skodowski Andreas Pohlmann Jason M Millward Friedemann Paul Jens Wuerfel Thoralf Niendorf Sonia Waiczies Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.
description	Inflammatory disorders of the central nervous system such as multiple sclerosis and acute disseminated encephalomyelitis involve an invasion of immune cells that ultimately leads to white matter demyelination, neurodegeneration and development of neurological symptoms. A clinical diagnosis is often made when neurodegenerative processes are already ongoing. In an attempt to seek early indicators of disease, we studied the temporal and spatial distribution of brain modifications in experimental autoimmune encephalomyelitis (EAE). In a thorough magnetic resonance imaging study performed with EAE mice, we observed significant enlargement of the ventricles prior to disease clinical manifestation and an increase in free water content within the cerebrospinal fluid as demonstrated by changes in T2 relaxation times. The increase in ventricle size was seen in the lateral, third and fourth ventricles. In some EAE mice the ventricle size started returning to normal values during disease remission. In parallel to this macroscopic phenomenon, we studied the temporal evolution of microscopic lesions commonly observed in the cerebellum also starting prior to disease onset. Our data suggest that changes in ventricle size during the early stages of brain inflammation could be an early indicator of the events preceding neurological disease and warrant further exploration in preclinical and clinical studies.
format	article
author	Stefano Lepore Helmar Waiczies Jan Hentschel Yiyi Ji Julia Skodowski Andreas Pohlmann Jason M Millward Friedemann Paul Jens Wuerfel Thoralf Niendorf Sonia Waiczies
author_facet	Stefano Lepore Helmar Waiczies Jan Hentschel Yiyi Ji Julia Skodowski Andreas Pohlmann Jason M Millward Friedemann Paul Jens Wuerfel Thoralf Niendorf Sonia Waiczies
author_sort	Stefano Lepore
title	Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.
title_short	Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.
title_full	Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.
title_fullStr	Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.
title_full_unstemmed	Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.
title_sort	enlargement of cerebral ventricles as an early indicator of encephalomyelitis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/620621b02c554a37817544c4df20a70b
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Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.

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