Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease

Chronic kidney disease (CKD) is a progressive damage of renal structure and function caused by various reasons. Its course is long and irreversible. CKD can be divided into 5 stages according to the glomerular filtration rate (GFR). Early detection and early intervention of CKD can reduce the compli...

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Autores principales:	Shihong Xiong, Ting Qi, Na Gong, Cheng Yang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/620660f156c04d54b117ae80e3de0d32
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spelling	oai:doaj.org-article:620660f156c04d54b117ae80e3de0d322021-11-08T02:36:19ZCorrelation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease1741-428810.1155/2021/6166528https://doaj.org/article/620660f156c04d54b117ae80e3de0d322021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6166528https://doaj.org/toc/1741-4288Chronic kidney disease (CKD) is a progressive damage of renal structure and function caused by various reasons. Its course is long and irreversible. CKD can be divided into 5 stages according to the glomerular filtration rate (GFR). Early detection and early intervention of CKD can reduce the complications of patients and improve the survival rate. Retinol-binding protein 4 (RBP4) is a small molecule transporter. Receptor for advanced glycation end products (RAGE) is a multi-ligand transmembrane signal transduction receptor discovered in recent years. Soluble RAGE (sRAGE) is a new splicing heterogeneity of RAGE. Our results show that serum RBP4 is increased while sRAGE is decreased in CKD patients, both of which are closely related to the severity of CKD. The combined use of serum RBP4 and sRAGE has a high diagnostic value for CKD and can provide a reliable diagnostic basis for the clinic.Shihong XiongTing QiNa GongCheng YangHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Shihong Xiong Ting Qi Na Gong Cheng Yang Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease
description	Chronic kidney disease (CKD) is a progressive damage of renal structure and function caused by various reasons. Its course is long and irreversible. CKD can be divided into 5 stages according to the glomerular filtration rate (GFR). Early detection and early intervention of CKD can reduce the complications of patients and improve the survival rate. Retinol-binding protein 4 (RBP4) is a small molecule transporter. Receptor for advanced glycation end products (RAGE) is a multi-ligand transmembrane signal transduction receptor discovered in recent years. Soluble RAGE (sRAGE) is a new splicing heterogeneity of RAGE. Our results show that serum RBP4 is increased while sRAGE is decreased in CKD patients, both of which are closely related to the severity of CKD. The combined use of serum RBP4 and sRAGE has a high diagnostic value for CKD and can provide a reliable diagnostic basis for the clinic.
format	article
author	Shihong Xiong Ting Qi Na Gong Cheng Yang
author_facet	Shihong Xiong Ting Qi Na Gong Cheng Yang
author_sort	Shihong Xiong
title	Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease
title_short	Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease
title_full	Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease
title_fullStr	Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease
title_full_unstemmed	Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease
title_sort	correlation and diagnostic value of serum rbp4 and srage and the condition of patients with chronic kidney disease
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/620660f156c04d54b117ae80e3de0d32
work_keys_str_mv	AT shihongxiong correlationanddiagnosticvalueofserumrbp4andsrageandtheconditionofpatientswithchronickidneydisease AT tingqi correlationanddiagnosticvalueofserumrbp4andsrageandtheconditionofpatientswithchronickidneydisease AT nagong correlationanddiagnosticvalueofserumrbp4andsrageandtheconditionofpatientswithchronickidneydisease AT chengyang correlationanddiagnosticvalueofserumrbp4andsrageandtheconditionofpatientswithchronickidneydisease
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Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease

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