Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration.
<h4>Objective</h4>HIV "elite controllers" (ECs) spontaneously control viral load, but some eventually require combination antiretroviral treatment (cART), due to a loss of viral control or a decline in CD4 T-cell counts. Here we studied the CD4 T-cell count dynamics after cART...
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2014
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oai:doaj.org-article:62095fc2fa104d77a0a9928f9048ddd62021-11-18T08:37:28ZBlunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration.1932-620310.1371/journal.pone.0085516https://doaj.org/article/62095fc2fa104d77a0a9928f9048ddd62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465584/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>HIV "elite controllers" (ECs) spontaneously control viral load, but some eventually require combination antiretroviral treatment (cART), due to a loss of viral control or a decline in CD4 T-cell counts. Here we studied the CD4 T-cell count dynamics after cART initiation among 34 ECs followed in U.S. and European cohorts, by comparison with chronically viremic patients (VIRs).<h4>Methods</h4>ECs were defined as patients with at least ≥5 viral load (VL) measurements below 400 copies/mL during at least a 5-year period despite never receiving ART and were selected from the French ANRS CO18 cohort, the U.S. SCOPE cohort, the International HIV Controllers study and the European CASCADE collaboration. VIRs were selected from the ANRS COPANA cohort of recently-diagnosed (<1 year) ART-naïve HIV-1-infected adults. CD4 T-cell count dynamics after cART initiation in both groups were modelled with piecewise mixed linear models.<h4>Results</h4>After cART initiation, CD4 T-cell counts showed a biphasic rise in VIRs with: an initial rapid increase during the first 3 months (+0.63√CD4/month), followed by +0.19√CD4/month. This first rapid phase was not observed in ECs, in whom the CD4Tc count increased steadily, at a rate similar to that of the second phase observed in VIRs. After cART initiation at a CD4 T-cell count of 300/mm(3), the estimated mean CD4 T-cell gain during the first 12 months was 139/mm(3) in VIRs and 80/mm(3) in ECs (p = 0.048).<h4>Conclusions</h4>cART increases CD4 T-cell counts in elite controllers, albeit less markedly than in other patients.Faroudy BoufassaJérome LechenadecLaurence MeyerDominique CostagliolaPeter W HuntFlorencia PereyraSteve DeeksGianfranco PancinoOlivier TauleraMathias LichterfeldPierre DelobelAsier Saez-CirionOlivier LambotteANRS CO18 HIV Controllers CohortCascade Collaboration in EurocoordSCOPE CohortInternational HIV Controllers StudyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85516 (2014) |
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Medicine R Science Q Faroudy Boufassa Jérome Lechenadec Laurence Meyer Dominique Costagliola Peter W Hunt Florencia Pereyra Steve Deeks Gianfranco Pancino Olivier Taulera Mathias Lichterfeld Pierre Delobel Asier Saez-Cirion Olivier Lambotte ANRS CO18 HIV Controllers Cohort Cascade Collaboration in Eurocoord SCOPE Cohort International HIV Controllers Study Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration. |
| description |
<h4>Objective</h4>HIV "elite controllers" (ECs) spontaneously control viral load, but some eventually require combination antiretroviral treatment (cART), due to a loss of viral control or a decline in CD4 T-cell counts. Here we studied the CD4 T-cell count dynamics after cART initiation among 34 ECs followed in U.S. and European cohorts, by comparison with chronically viremic patients (VIRs).<h4>Methods</h4>ECs were defined as patients with at least ≥5 viral load (VL) measurements below 400 copies/mL during at least a 5-year period despite never receiving ART and were selected from the French ANRS CO18 cohort, the U.S. SCOPE cohort, the International HIV Controllers study and the European CASCADE collaboration. VIRs were selected from the ANRS COPANA cohort of recently-diagnosed (<1 year) ART-naïve HIV-1-infected adults. CD4 T-cell count dynamics after cART initiation in both groups were modelled with piecewise mixed linear models.<h4>Results</h4>After cART initiation, CD4 T-cell counts showed a biphasic rise in VIRs with: an initial rapid increase during the first 3 months (+0.63√CD4/month), followed by +0.19√CD4/month. This first rapid phase was not observed in ECs, in whom the CD4Tc count increased steadily, at a rate similar to that of the second phase observed in VIRs. After cART initiation at a CD4 T-cell count of 300/mm(3), the estimated mean CD4 T-cell gain during the first 12 months was 139/mm(3) in VIRs and 80/mm(3) in ECs (p = 0.048).<h4>Conclusions</h4>cART increases CD4 T-cell counts in elite controllers, albeit less markedly than in other patients. |
| format |
article |
| author |
Faroudy Boufassa Jérome Lechenadec Laurence Meyer Dominique Costagliola Peter W Hunt Florencia Pereyra Steve Deeks Gianfranco Pancino Olivier Taulera Mathias Lichterfeld Pierre Delobel Asier Saez-Cirion Olivier Lambotte ANRS CO18 HIV Controllers Cohort Cascade Collaboration in Eurocoord SCOPE Cohort International HIV Controllers Study |
| author_facet |
Faroudy Boufassa Jérome Lechenadec Laurence Meyer Dominique Costagliola Peter W Hunt Florencia Pereyra Steve Deeks Gianfranco Pancino Olivier Taulera Mathias Lichterfeld Pierre Delobel Asier Saez-Cirion Olivier Lambotte ANRS CO18 HIV Controllers Cohort Cascade Collaboration in Eurocoord SCOPE Cohort International HIV Controllers Study |
| author_sort |
Faroudy Boufassa |
| title |
Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration. |
| title_short |
Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration. |
| title_full |
Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration. |
| title_fullStr |
Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration. |
| title_full_unstemmed |
Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration. |
| title_sort |
blunted response to combination antiretroviral therapy in hiv elite controllers: an international hiv controller collaboration. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/62095fc2fa104d77a0a9928f9048ddd6 |
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