Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma

BACKGROUND AND OBJECTIVE: Human Papillomavirus (HPV) plays an important role in the genesis of cancers of cervix and oral cavity. Squamous epithelium of esophagus is an appropriate site for HPV infection. The aim of this study was to determine the correlation of this infection with esophageal squamo...

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Autores principales:	O Emadian, F Naghshvar, AR Rafiei, E Maleki, J Torabizadeh, Rezaei Far
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	human papillomaviruses esophageal squamous cell carcinoma polymerase chain reaction (pcr) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6209983a1e8d47ccba52dd5b0558bf28
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spelling	oai:doaj.org-article:6209983a1e8d47ccba52dd5b0558bf282021-11-10T08:56:42ZCorrelation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma1561-41072251-7170https://doaj.org/article/6209983a1e8d47ccba52dd5b0558bf282011-07-01T00:00:00Zhttp://jbums.org/article-1-3843-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Human Papillomavirus (HPV) plays an important role in the genesis of cancers of cervix and oral cavity. Squamous epithelium of esophagus is an appropriate site for HPV infection. The aim of this study was to determine the correlation of this infection with esophageal squamous cell carcinoma (ESCC).METHODS: In a case-control study forty cases of ESCC and forty controls with nonmalignant specimens from the patients referred to Imam Khomeini hospital–Sari (Mazandaran, Iran) during eight years (2001-2008) were enrolled. Extracted DNAs from the specimens were analyzed for HPV DNA with the commercial kits available for HPV.FINDINGS: Fifteen (37.5%) cases of ESCC and 5 (12.5%) specimens of controls were positive for HPV DNA (p=0.03). The most common genotypes in the ESCC patients and control group were HPV16 & HPV45 (each 15% for ESCC patients HPV16 7.5% and HPV45 five percent for the controls). There was no significant difference for HPV genotype and patient’s age, sex or tumor’s stage and grade.CONCLUSION: HPV may be counted as an important risk factor for ESCC in northern region of Iran.O EmadianF NaghshvarAR RafieiE MalekiJ TorabizadehRezaei FarBabol University of Medical Sciencesarticlehuman papillomavirusesesophageal squamous cell carcinomapolymerase chain reaction (pcr)MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 4, Pp 54-59 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	human papillomaviruses esophageal squamous cell carcinoma polymerase chain reaction (pcr) Medicine R Medicine (General) R5-920
spellingShingle	human papillomaviruses esophageal squamous cell carcinoma polymerase chain reaction (pcr) Medicine R Medicine (General) R5-920 O Emadian F Naghshvar AR Rafiei E Maleki J Torabizadeh Rezaei Far Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma
description	BACKGROUND AND OBJECTIVE: Human Papillomavirus (HPV) plays an important role in the genesis of cancers of cervix and oral cavity. Squamous epithelium of esophagus is an appropriate site for HPV infection. The aim of this study was to determine the correlation of this infection with esophageal squamous cell carcinoma (ESCC).METHODS: In a case-control study forty cases of ESCC and forty controls with nonmalignant specimens from the patients referred to Imam Khomeini hospital–Sari (Mazandaran, Iran) during eight years (2001-2008) were enrolled. Extracted DNAs from the specimens were analyzed for HPV DNA with the commercial kits available for HPV.FINDINGS: Fifteen (37.5%) cases of ESCC and 5 (12.5%) specimens of controls were positive for HPV DNA (p=0.03). The most common genotypes in the ESCC patients and control group were HPV16 & HPV45 (each 15% for ESCC patients HPV16 7.5% and HPV45 five percent for the controls). There was no significant difference for HPV genotype and patient’s age, sex or tumor’s stage and grade.CONCLUSION: HPV may be counted as an important risk factor for ESCC in northern region of Iran.
format	article
author	O Emadian F Naghshvar AR Rafiei E Maleki J Torabizadeh Rezaei Far
author_facet	O Emadian F Naghshvar AR Rafiei E Maleki J Torabizadeh Rezaei Far
author_sort	O Emadian
title	Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma
title_short	Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma
title_full	Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma
title_fullStr	Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma
title_full_unstemmed	Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma
title_sort	correlation of human papillomavirus infection with esophageal squamous cell carcinoma
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/6209983a1e8d47ccba52dd5b0558bf28
work_keys_str_mv	AT oemadian correlationofhumanpapillomavirusinfectionwithesophagealsquamouscellcarcinoma AT fnaghshvar correlationofhumanpapillomavirusinfectionwithesophagealsquamouscellcarcinoma AT arrafiei correlationofhumanpapillomavirusinfectionwithesophagealsquamouscellcarcinoma AT emaleki correlationofhumanpapillomavirusinfectionwithesophagealsquamouscellcarcinoma AT jtorabizadeh correlationofhumanpapillomavirusinfectionwithesophagealsquamouscellcarcinoma AT rezaeifar correlationofhumanpapillomavirusinfectionwithesophagealsquamouscellcarcinoma
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Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma

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