Deleterious Role of Th9 Cells in Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown etiology. Immune disorders play an important role in IPF pathogenesis. Here, we show that Th9 cells differentiate and activate in the lung tissue of patients with IPF and bleomycin (BLM)-induced lung fibrosis mice...

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Autores principales:	Kui Miao Deng, Xiang Sheng Yang, Qun Luo, Yi Xin She, Qing Yang Yu, Xiao Xiao Tang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	idiopathic pulmonary fibrosis Th9 cells Th2 cells interleukin-9 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6209b4965f4b465b998879e29900aee2
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spelling	oai:doaj.org-article:6209b4965f4b465b998879e29900aee22021-11-25T17:12:56ZDeleterious Role of Th9 Cells in Pulmonary Fibrosis10.3390/cells101132092073-4409https://doaj.org/article/6209b4965f4b465b998879e29900aee22021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3209https://doaj.org/toc/2073-4409Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown etiology. Immune disorders play an important role in IPF pathogenesis. Here, we show that Th9 cells differentiate and activate in the lung tissue of patients with IPF and bleomycin (BLM)-induced lung fibrosis mice. Moreover, we found that Th9 cells promote pulmonary fibrosis in two ways. On the one hand, Th9 cells promote fibroblast differentiation, activation, and collagen secretion by secreting IL-9. On the other hand, they promote differentiation of Th0 cells into Th2 cells by secreting IL-4. Th9 cells and Th2 cells can promote each other, accelerating the Th1/Th2 imbalance and eventually forming a positive feedback of pulmonary fibrosis. In addition, we found that neutralizing IL-9 in both preventive and therapeutic settings ameliorates bleomycin-induced pulmonary fibrosis. Furthermore, we identified several critical signaling pathways involved in the effect of neutralizing IL-9 on pulmonary fibrosis by proteomics study. From an immunological perspective, we elucidated the novel role and underlying mechanism of Th9 cells in pulmonary fibrosis. Our study suggested that Th9-based immunotherapy may be employed as a treatment strategy for IPF.Kui Miao DengXiang Sheng YangQun LuoYi Xin SheQing Yang YuXiao Xiao TangMDPI AGarticleidiopathic pulmonary fibrosisTh9 cellsTh2 cellsinterleukin-9Biology (General)QH301-705.5ENCells, Vol 10, Iss 3209, p 3209 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic pulmonary fibrosis Th9 cells Th2 cells interleukin-9 Biology (General) QH301-705.5
spellingShingle	idiopathic pulmonary fibrosis Th9 cells Th2 cells interleukin-9 Biology (General) QH301-705.5 Kui Miao Deng Xiang Sheng Yang Qun Luo Yi Xin She Qing Yang Yu Xiao Xiao Tang Deleterious Role of Th9 Cells in Pulmonary Fibrosis
description	Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown etiology. Immune disorders play an important role in IPF pathogenesis. Here, we show that Th9 cells differentiate and activate in the lung tissue of patients with IPF and bleomycin (BLM)-induced lung fibrosis mice. Moreover, we found that Th9 cells promote pulmonary fibrosis in two ways. On the one hand, Th9 cells promote fibroblast differentiation, activation, and collagen secretion by secreting IL-9. On the other hand, they promote differentiation of Th0 cells into Th2 cells by secreting IL-4. Th9 cells and Th2 cells can promote each other, accelerating the Th1/Th2 imbalance and eventually forming a positive feedback of pulmonary fibrosis. In addition, we found that neutralizing IL-9 in both preventive and therapeutic settings ameliorates bleomycin-induced pulmonary fibrosis. Furthermore, we identified several critical signaling pathways involved in the effect of neutralizing IL-9 on pulmonary fibrosis by proteomics study. From an immunological perspective, we elucidated the novel role and underlying mechanism of Th9 cells in pulmonary fibrosis. Our study suggested that Th9-based immunotherapy may be employed as a treatment strategy for IPF.
format	article
author	Kui Miao Deng Xiang Sheng Yang Qun Luo Yi Xin She Qing Yang Yu Xiao Xiao Tang
author_facet	Kui Miao Deng Xiang Sheng Yang Qun Luo Yi Xin She Qing Yang Yu Xiao Xiao Tang
author_sort	Kui Miao Deng
title	Deleterious Role of Th9 Cells in Pulmonary Fibrosis
title_short	Deleterious Role of Th9 Cells in Pulmonary Fibrosis
title_full	Deleterious Role of Th9 Cells in Pulmonary Fibrosis
title_fullStr	Deleterious Role of Th9 Cells in Pulmonary Fibrosis
title_full_unstemmed	Deleterious Role of Th9 Cells in Pulmonary Fibrosis
title_sort	deleterious role of th9 cells in pulmonary fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6209b4965f4b465b998879e29900aee2
work_keys_str_mv	AT kuimiaodeng deleteriousroleofth9cellsinpulmonaryfibrosis AT xiangshengyang deleteriousroleofth9cellsinpulmonaryfibrosis AT qunluo deleteriousroleofth9cellsinpulmonaryfibrosis AT yixinshe deleteriousroleofth9cellsinpulmonaryfibrosis AT qingyangyu deleteriousroleofth9cellsinpulmonaryfibrosis AT xiaoxiaotang deleteriousroleofth9cellsinpulmonaryfibrosis
_version_	1718412591505604608

Deleterious Role of Th9 Cells in Pulmonary Fibrosis

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