Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer

In this study, the authors show that that oncogenic hijacking of PRC1 sensitizes genomically stable Ewing sarcoma cells for PLK1 inhibition alone or in synergy with a microtubule-destabilizing drug via induction of cytokinesis defects, rendering PRC1 a promising, broadly applicable predictive biomar...

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Autores principales:	Jing Li, Shunya Ohmura, Aruna Marchetto, Martin F. Orth, Roland Imle, Marlene Dallmayer, Julian Musa, Maximilian M. L. Knott, Tilman L. B. Hölting, Stefanie Stein, Cornelius M. Funk, Ana Sastre, Javier Alonso, Felix Bestvater, Merve Kasan, Laura Romero-Pérez, Wolfgang Hartmann, Andreas Ranft, Ana Banito, Uta Dirksen, Thomas Kirchner, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/620b86da89cd44d2bbf793a753d0ae4f
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spelling	oai:doaj.org-article:620b86da89cd44d2bbf793a753d0ae4f2021-12-02T17:23:48ZTherapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer10.1038/s41467-021-25553-z2041-1723https://doaj.org/article/620b86da89cd44d2bbf793a753d0ae4f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25553-zhttps://doaj.org/toc/2041-1723In this study, the authors show that that oncogenic hijacking of PRC1 sensitizes genomically stable Ewing sarcoma cells for PLK1 inhibition alone or in synergy with a microtubule-destabilizing drug via induction of cytokinesis defects, rendering PRC1 a promising, broadly applicable predictive biomarkerJing LiShunya OhmuraAruna MarchettoMartin F. OrthRoland ImleMarlene DallmayerJulian MusaMaximilian M. L. KnottTilman L. B. HöltingStefanie SteinCornelius M. FunkAna SastreJavier AlonsoFelix BestvaterMerve KasanLaura Romero-PérezWolfgang HartmannAndreas RanftAna BanitoUta DirksenThomas KirchnerFlorencia Cidre-AranazThomas G. P. GrünewaldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Li Shunya Ohmura Aruna Marchetto Martin F. Orth Roland Imle Marlene Dallmayer Julian Musa Maximilian M. L. Knott Tilman L. B. Hölting Stefanie Stein Cornelius M. Funk Ana Sastre Javier Alonso Felix Bestvater Merve Kasan Laura Romero-Pérez Wolfgang Hartmann Andreas Ranft Ana Banito Uta Dirksen Thomas Kirchner Florencia Cidre-Aranaz Thomas G. P. Grünewald Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
description	In this study, the authors show that that oncogenic hijacking of PRC1 sensitizes genomically stable Ewing sarcoma cells for PLK1 inhibition alone or in synergy with a microtubule-destabilizing drug via induction of cytokinesis defects, rendering PRC1 a promising, broadly applicable predictive biomarker
format	article
author	Jing Li Shunya Ohmura Aruna Marchetto Martin F. Orth Roland Imle Marlene Dallmayer Julian Musa Maximilian M. L. Knott Tilman L. B. Hölting Stefanie Stein Cornelius M. Funk Ana Sastre Javier Alonso Felix Bestvater Merve Kasan Laura Romero-Pérez Wolfgang Hartmann Andreas Ranft Ana Banito Uta Dirksen Thomas Kirchner Florencia Cidre-Aranaz Thomas G. P. Grünewald
author_facet	Jing Li Shunya Ohmura Aruna Marchetto Martin F. Orth Roland Imle Marlene Dallmayer Julian Musa Maximilian M. L. Knott Tilman L. B. Hölting Stefanie Stein Cornelius M. Funk Ana Sastre Javier Alonso Felix Bestvater Merve Kasan Laura Romero-Pérez Wolfgang Hartmann Andreas Ranft Ana Banito Uta Dirksen Thomas Kirchner Florencia Cidre-Aranaz Thomas G. P. Grünewald
author_sort	Jing Li
title	Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
title_short	Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
title_full	Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
title_fullStr	Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
title_full_unstemmed	Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
title_sort	therapeutic targeting of the plk1-prc1-axis triggers cell death in genomically silent childhood cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/620b86da89cd44d2bbf793a753d0ae4f
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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer

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