Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial

Abstract This study aimed to evaluate the clinical evolution, functional parameters and inflammatory activity of asthma in patients who submitted to an educational intervention. 58 adult patients over 18 years of age with partly controlled and uncontrolled asthma were randomized into an intervention...

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Autores principales:	Soraia Nogueira Felix, Rosana Câmara Agondi, Marcelo Vivolo Aun, Clarice Rosa Olivo, Francine Maria de Almeida, Thais Santos Amorim, Julia Caroline Cezario, Pedro Giavina-Bianchi, Iolanda de Fátima Lopes Calvo Tiberio, Milton de Arruda de Martins, Beatriz Mangueira Saraiva Romanholo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/620c6b5dc1404e029393e477ff23b989
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spelling	oai:doaj.org-article:620c6b5dc1404e029393e477ff23b9892021-12-02T18:34:01ZClinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial10.1038/s41598-021-97846-82045-2322https://doaj.org/article/620c6b5dc1404e029393e477ff23b9892021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97846-8https://doaj.org/toc/2045-2322Abstract This study aimed to evaluate the clinical evolution, functional parameters and inflammatory activity of asthma in patients who submitted to an educational intervention. 58 adult patients over 18 years of age with partly controlled and uncontrolled asthma were randomized into an intervention group (IG) (N = 32) and a control group (CG) (N = 26) and evaluated for 12 weeks. The Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ) and Beck Depression Inventory (BDI) questionnaires were applied. Spirometry, exhaled nitric oxide (NO), exhaled breath condensate (EBC) and induced sputum (IS), measurement of the peak flow and symptoms were performed. The IG patients received an educational activity for 30 min applied by a nurse. Statistical analysis: analysis of variance with repeated intragroup measures. IG presented a decreased number of eosinophils in IS and IL-17A in EBC, an increase in the percentage of FEV1 before and after bronchodilator and an improvement in quality of life compared to the CG. There was an improvement in depression levels and a decrease in IL-4 and IL-5 in the IS and in the EBC in both groups. Our results suggest that an educational intervention can bring benefits concerning the control of inflammation, lung function alterations, quality of life and levels of depression in asthmatic patients. Registration: ClinicalTrials.gov; NCT03655392.Soraia Nogueira FelixRosana Câmara AgondiMarcelo Vivolo AunClarice Rosa OlivoFrancine Maria de AlmeidaThais Santos AmorimJulia Caroline CezarioPedro Giavina-BianchiIolanda de Fátima Lopes Calvo TiberioMilton de Arruda de MartinsBeatriz Mangueira Saraiva RomanholoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soraia Nogueira Felix Rosana Câmara Agondi Marcelo Vivolo Aun Clarice Rosa Olivo Francine Maria de Almeida Thais Santos Amorim Julia Caroline Cezario Pedro Giavina-Bianchi Iolanda de Fátima Lopes Calvo Tiberio Milton de Arruda de Martins Beatriz Mangueira Saraiva Romanholo Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
description	Abstract This study aimed to evaluate the clinical evolution, functional parameters and inflammatory activity of asthma in patients who submitted to an educational intervention. 58 adult patients over 18 years of age with partly controlled and uncontrolled asthma were randomized into an intervention group (IG) (N = 32) and a control group (CG) (N = 26) and evaluated for 12 weeks. The Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ) and Beck Depression Inventory (BDI) questionnaires were applied. Spirometry, exhaled nitric oxide (NO), exhaled breath condensate (EBC) and induced sputum (IS), measurement of the peak flow and symptoms were performed. The IG patients received an educational activity for 30 min applied by a nurse. Statistical analysis: analysis of variance with repeated intragroup measures. IG presented a decreased number of eosinophils in IS and IL-17A in EBC, an increase in the percentage of FEV1 before and after bronchodilator and an improvement in quality of life compared to the CG. There was an improvement in depression levels and a decrease in IL-4 and IL-5 in the IS and in the EBC in both groups. Our results suggest that an educational intervention can bring benefits concerning the control of inflammation, lung function alterations, quality of life and levels of depression in asthmatic patients. Registration: ClinicalTrials.gov; NCT03655392.
format	article
author	Soraia Nogueira Felix Rosana Câmara Agondi Marcelo Vivolo Aun Clarice Rosa Olivo Francine Maria de Almeida Thais Santos Amorim Julia Caroline Cezario Pedro Giavina-Bianchi Iolanda de Fátima Lopes Calvo Tiberio Milton de Arruda de Martins Beatriz Mangueira Saraiva Romanholo
author_facet	Soraia Nogueira Felix Rosana Câmara Agondi Marcelo Vivolo Aun Clarice Rosa Olivo Francine Maria de Almeida Thais Santos Amorim Julia Caroline Cezario Pedro Giavina-Bianchi Iolanda de Fátima Lopes Calvo Tiberio Milton de Arruda de Martins Beatriz Mangueira Saraiva Romanholo
author_sort	Soraia Nogueira Felix
title	Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
title_short	Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
title_full	Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
title_fullStr	Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
title_full_unstemmed	Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
title_sort	clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/620c6b5dc1404e029393e477ff23b989
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Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial

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