Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions

Mohamed A Elblbesy Department of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, EgyptCorrespondence: Mohamed A ElblbesyDepartment of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, EgyptEmail mimizizo@yahoo.comIntroduction: Eryth...

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Autor principal:	Elblbesy MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Electrical analysis erythrocytes aggregation coagulation Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/620c9f3ac8bd4398a90f920d94bd796d
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spelling	oai:doaj.org-article:620c9f3ac8bd4398a90f920d94bd796d2021-12-02T07:41:52ZElectrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions1179-1470https://doaj.org/article/620c9f3ac8bd4398a90f920d94bd796d2019-10-01T00:00:00Zhttps://www.dovepress.com/electrical-analysis-of-normal-and-diabetic-blood-for-evaluation-of-agg-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Mohamed A Elblbesy Department of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, EgyptCorrespondence: Mohamed A ElblbesyDepartment of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, EgyptEmail mimizizo@yahoo.comIntroduction: Erythrocyte aggregation and blood coagulation are of great interest and are still under investigation by many researchers. Erythrocytes have a direct effect on hemorheological properties. Real-time in vitro studies on blood coagulation and aggregation provide a chance to understand their mechanisms in normal and pathological conditions. Additionally, this method offers control over the physical and chemical conditions during the study.Objective: The present study introduced a simple in vitro technique to study blood aggregation and coagulation under controlled conditions.Methods: The technique used in this study is based on the measurement of the electrical properties of blood. A simple flow chamber was made from two cylinders with a gap between them. The outer cylinder remains stationary, and the inner cylinder rotates about its axis. The inner cylinder velocity is controlled by a stepper motor. Blood samples are introduced in the gap between the two cylinders. Capacitance and impedance of blood samples were recorded by two electrodes attached to the outer cylinders and in direct contact with blood.Results: Quantitative parameters were extracted from the capacitance and impedance time courses. These parameters were used to describe the aggregation and coagulation processes under different shear rates. Strong correlations between the aggregation index and shear rate were found for normal and diabetic blood samples. Additionally, strong negative correlations of coagulation time were found for normal and diabetic blood samples. In conclusion, the electrical analysis of blood reflects well the interactions between internal blood contents.Conclusion: The parameters extracted from this technique can be used in the quantitative description of hemorheological processes under different physical conditions.Keywords: electrical analysis, erythrocytes, aggregation, coagulationElblbesy MADove Medical PressarticleElectrical analysiserythrocytesaggregationcoagulationMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol Volume 12, Pp 435-442 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electrical analysis erythrocytes aggregation coagulation Medical technology R855-855.5
spellingShingle	Electrical analysis erythrocytes aggregation coagulation Medical technology R855-855.5 Elblbesy MA Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions
description	Mohamed A Elblbesy Department of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, EgyptCorrespondence: Mohamed A ElblbesyDepartment of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, EgyptEmail mimizizo@yahoo.comIntroduction: Erythrocyte aggregation and blood coagulation are of great interest and are still under investigation by many researchers. Erythrocytes have a direct effect on hemorheological properties. Real-time in vitro studies on blood coagulation and aggregation provide a chance to understand their mechanisms in normal and pathological conditions. Additionally, this method offers control over the physical and chemical conditions during the study.Objective: The present study introduced a simple in vitro technique to study blood aggregation and coagulation under controlled conditions.Methods: The technique used in this study is based on the measurement of the electrical properties of blood. A simple flow chamber was made from two cylinders with a gap between them. The outer cylinder remains stationary, and the inner cylinder rotates about its axis. The inner cylinder velocity is controlled by a stepper motor. Blood samples are introduced in the gap between the two cylinders. Capacitance and impedance of blood samples were recorded by two electrodes attached to the outer cylinders and in direct contact with blood.Results: Quantitative parameters were extracted from the capacitance and impedance time courses. These parameters were used to describe the aggregation and coagulation processes under different shear rates. Strong correlations between the aggregation index and shear rate were found for normal and diabetic blood samples. Additionally, strong negative correlations of coagulation time were found for normal and diabetic blood samples. In conclusion, the electrical analysis of blood reflects well the interactions between internal blood contents.Conclusion: The parameters extracted from this technique can be used in the quantitative description of hemorheological processes under different physical conditions.Keywords: electrical analysis, erythrocytes, aggregation, coagulation
format	article
author	Elblbesy MA
author_facet	Elblbesy MA
author_sort	Elblbesy MA
title	Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions
title_short	Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions
title_full	Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions
title_fullStr	Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions
title_full_unstemmed	Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions
title_sort	electrical analysis of normal and diabetic blood for evaluation of aggregation and coagulation under different rheological conditions
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/620c9f3ac8bd4398a90f920d94bd796d
work_keys_str_mv	AT elblbesyma electricalanalysisofnormalanddiabeticbloodforevaluationofaggregationandcoagulationunderdifferentrheologicalconditions
_version_	1718399227084668928

Electrical Analysis Of Normal And Diabetic Blood For Evaluation Of Aggregation And Coagulation Under Different Rheological Conditions

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