Testicular inducing steroidogenic cells trigger sex change in groupers

Abstract Vertebrates usually exhibit gonochorism, whereby their sex is fixed throughout their lifetime. However, approximately 500 species (~ 2%) of extant teleost fishes change sex during their lifetime. Although phylogenetic and evolutionary ecological studies have recently revealed that the extan...

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Autores principales:	Ryosuke Murata, Ryo Nozu, Yuji Mushirobira, Takafumi Amagai, Jun Fushimi, Yasuhisa Kobayashi, Kiyoshi Soyano, Yoshitaka Nagahama, Masaru Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/620fc10ec8c54983afb8069d72b45262
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spelling	oai:doaj.org-article:620fc10ec8c54983afb8069d72b452622021-12-02T16:53:00ZTesticular inducing steroidogenic cells trigger sex change in groupers10.1038/s41598-021-90691-92045-2322https://doaj.org/article/620fc10ec8c54983afb8069d72b452622021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90691-9https://doaj.org/toc/2045-2322Abstract Vertebrates usually exhibit gonochorism, whereby their sex is fixed throughout their lifetime. However, approximately 500 species (~ 2%) of extant teleost fishes change sex during their lifetime. Although phylogenetic and evolutionary ecological studies have recently revealed that the extant sequential hermaphroditism in teleost fish is derived from gonochorism, the evolution of this transsexual ability remains unclear. We revealed in a previous study that the tunica of the ovaries of several protogynous hermaphrodite groupers contain functional androgen-producing cells, which were previously unknown structures in the ovaries of gonochoristic fishes. Additionally, we demonstrated that these androgen-producing cells play critical roles in initiating female-to-male sex change in several grouper species. In the present study, we widened the investigation to include 7 genera and 18 species of groupers and revealed that representatives from most major clades of extant groupers commonly contain these androgen-producing cells, termed testicular-inducing steroidogenic (TIS) cells. Our findings suggest that groupers acquired TIS cells in the tunica of the gonads for successful sex change during their evolution. Thus, TIS cells trigger the evolution of sex change in groupers.Ryosuke MurataRyo NozuYuji MushirobiraTakafumi AmagaiJun FushimiYasuhisa KobayashiKiyoshi SoyanoYoshitaka NagahamaMasaru NakamuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryosuke Murata Ryo Nozu Yuji Mushirobira Takafumi Amagai Jun Fushimi Yasuhisa Kobayashi Kiyoshi Soyano Yoshitaka Nagahama Masaru Nakamura Testicular inducing steroidogenic cells trigger sex change in groupers
description	Abstract Vertebrates usually exhibit gonochorism, whereby their sex is fixed throughout their lifetime. However, approximately 500 species (~ 2%) of extant teleost fishes change sex during their lifetime. Although phylogenetic and evolutionary ecological studies have recently revealed that the extant sequential hermaphroditism in teleost fish is derived from gonochorism, the evolution of this transsexual ability remains unclear. We revealed in a previous study that the tunica of the ovaries of several protogynous hermaphrodite groupers contain functional androgen-producing cells, which were previously unknown structures in the ovaries of gonochoristic fishes. Additionally, we demonstrated that these androgen-producing cells play critical roles in initiating female-to-male sex change in several grouper species. In the present study, we widened the investigation to include 7 genera and 18 species of groupers and revealed that representatives from most major clades of extant groupers commonly contain these androgen-producing cells, termed testicular-inducing steroidogenic (TIS) cells. Our findings suggest that groupers acquired TIS cells in the tunica of the gonads for successful sex change during their evolution. Thus, TIS cells trigger the evolution of sex change in groupers.
format	article
author	Ryosuke Murata Ryo Nozu Yuji Mushirobira Takafumi Amagai Jun Fushimi Yasuhisa Kobayashi Kiyoshi Soyano Yoshitaka Nagahama Masaru Nakamura
author_facet	Ryosuke Murata Ryo Nozu Yuji Mushirobira Takafumi Amagai Jun Fushimi Yasuhisa Kobayashi Kiyoshi Soyano Yoshitaka Nagahama Masaru Nakamura
author_sort	Ryosuke Murata
title	Testicular inducing steroidogenic cells trigger sex change in groupers
title_short	Testicular inducing steroidogenic cells trigger sex change in groupers
title_full	Testicular inducing steroidogenic cells trigger sex change in groupers
title_fullStr	Testicular inducing steroidogenic cells trigger sex change in groupers
title_full_unstemmed	Testicular inducing steroidogenic cells trigger sex change in groupers
title_sort	testicular inducing steroidogenic cells trigger sex change in groupers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/620fc10ec8c54983afb8069d72b45262
work_keys_str_mv	AT ryosukemurata testicularinducingsteroidogeniccellstriggersexchangeingroupers AT ryonozu testicularinducingsteroidogeniccellstriggersexchangeingroupers AT yujimushirobira testicularinducingsteroidogeniccellstriggersexchangeingroupers AT takafumiamagai testicularinducingsteroidogeniccellstriggersexchangeingroupers AT junfushimi testicularinducingsteroidogeniccellstriggersexchangeingroupers AT yasuhisakobayashi testicularinducingsteroidogeniccellstriggersexchangeingroupers AT kiyoshisoyano testicularinducingsteroidogeniccellstriggersexchangeingroupers AT yoshitakanagahama testicularinducingsteroidogeniccellstriggersexchangeingroupers AT masarunakamura testicularinducingsteroidogeniccellstriggersexchangeingroupers
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Testicular inducing steroidogenic cells trigger sex change in groupers

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