A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis

The potassium channel KCNK9 mediates important biological processes and is often overexpressed in breast and lung cancers. In this study, the authors developed a specific monoclonal antibody against the extracellular domain of KCNK9 and show that it inhibits cancer growth and metastasis in vivothrou...

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Autores principales:	Han Sun, Liqun Luo, Bachchu Lal, Xinrong Ma, Lieping Chen, Christine L. Hann, Amy M. Fulton, Daniel J. Leahy, John Laterra, Min Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/621136ed5d044eb9bc72178de246e111
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spelling	oai:doaj.org-article:621136ed5d044eb9bc72178de246e1112021-12-02T17:31:51ZA monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis10.1038/ncomms103392041-1723https://doaj.org/article/621136ed5d044eb9bc72178de246e1112016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10339https://doaj.org/toc/2041-1723The potassium channel KCNK9 mediates important biological processes and is often overexpressed in breast and lung cancers. In this study, the authors developed a specific monoclonal antibody against the extracellular domain of KCNK9 and show that it inhibits cancer growth and metastasis in vivothrough both cell autonomous and immune-dependent cellular cytotoxicity.Han SunLiqun LuoBachchu LalXinrong MaLieping ChenChristine L. HannAmy M. FultonDaniel J. LeahyJohn LaterraMin LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Han Sun Liqun Luo Bachchu Lal Xinrong Ma Lieping Chen Christine L. Hann Amy M. Fulton Daniel J. Leahy John Laterra Min Li A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
description	The potassium channel KCNK9 mediates important biological processes and is often overexpressed in breast and lung cancers. In this study, the authors developed a specific monoclonal antibody against the extracellular domain of KCNK9 and show that it inhibits cancer growth and metastasis in vivothrough both cell autonomous and immune-dependent cellular cytotoxicity.
format	article
author	Han Sun Liqun Luo Bachchu Lal Xinrong Ma Lieping Chen Christine L. Hann Amy M. Fulton Daniel J. Leahy John Laterra Min Li
author_facet	Han Sun Liqun Luo Bachchu Lal Xinrong Ma Lieping Chen Christine L. Hann Amy M. Fulton Daniel J. Leahy John Laterra Min Li
author_sort	Han Sun
title	A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
title_short	A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
title_full	A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
title_fullStr	A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
title_full_unstemmed	A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
title_sort	monoclonal antibody against kcnk9 k+ channel extracellular domain inhibits tumour growth and metastasis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/621136ed5d044eb9bc72178de246e111
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A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis

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