Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach

This biomonitoring study was conducted to investigate the concentration levels of five <i>Alternaria</i> mycotoxins in urine samples from 269 healthy volunteers living in the Yangtze River Delta, China. Alternariol (AOH), alternariol monomethyl ether (AME), tenuazonic acid (TeA) and tent...

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Autores principales:	Kai Fan, Wenbo Guo, Qingwen Huang, Jiajia Meng, Qi Yao, Dongxia Nie, Zheng Han, Zhihui Zhao
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Alternaria</i> mycotoxin human urine UPLC-MS/MS risk assessment Medicine R
Acceso en línea:	https://doaj.org/article/6213e7580c7f45d9a07b548ea1c45ad8
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spelling	oai:doaj.org-article:6213e7580c7f45d9a07b548ea1c45ad82021-11-25T19:08:38ZAssessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach10.3390/toxins131107622072-6651https://doaj.org/article/6213e7580c7f45d9a07b548ea1c45ad82021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/762https://doaj.org/toc/2072-6651This biomonitoring study was conducted to investigate the concentration levels of five <i>Alternaria</i> mycotoxins in urine samples from 269 healthy volunteers living in the Yangtze River Delta, China. Alternariol (AOH), alternariol monomethyl ether (AME), tenuazonic acid (TeA) and tentoxin (TEN) were detected in 38.3%, 48.7%, 63.9% and 23.4% of urine samples with the concentrations ranging from 0.057 to 45.8 ng/mL, 0.020 to 0.802 ng/mL, 0.050 to 80.6 ng/mL and 0.021 to 0.939 ng/mL, respectively. Altenuene (ALT) was not detected in any urine sample. Based on the urinary concentrations, the probable daily intake (PDI) values of <i>Alternaria</i> mycotoxins were calculated, and 100%, 99.2–100%, 0.372% and 1.12% of participants exceeded the threshold of toxicological concern (TTC) values for AOH, AME, TeA and TEN, respectively. This study revealed high potential health risks related to the contaminations of major <i>Alternaria</i> mycotoxins in China and highlighted the necessity for more toxicological studies to provide better basis for further comprehensive risk assessments.Kai FanWenbo GuoQingwen HuangJiajia MengQi YaoDongxia NieZheng HanZhihui ZhaoMDPI AGarticle<i>Alternaria</i> mycotoxinhuman urineUPLC-MS/MSrisk assessmentMedicineRENToxins, Vol 13, Iss 762, p 762 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Alternaria</i> mycotoxin human urine UPLC-MS/MS risk assessment Medicine R
spellingShingle	<i>Alternaria</i> mycotoxin human urine UPLC-MS/MS risk assessment Medicine R Kai Fan Wenbo Guo Qingwen Huang Jiajia Meng Qi Yao Dongxia Nie Zheng Han Zhihui Zhao Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach
description	This biomonitoring study was conducted to investigate the concentration levels of five <i>Alternaria</i> mycotoxins in urine samples from 269 healthy volunteers living in the Yangtze River Delta, China. Alternariol (AOH), alternariol monomethyl ether (AME), tenuazonic acid (TeA) and tentoxin (TEN) were detected in 38.3%, 48.7%, 63.9% and 23.4% of urine samples with the concentrations ranging from 0.057 to 45.8 ng/mL, 0.020 to 0.802 ng/mL, 0.050 to 80.6 ng/mL and 0.021 to 0.939 ng/mL, respectively. Altenuene (ALT) was not detected in any urine sample. Based on the urinary concentrations, the probable daily intake (PDI) values of <i>Alternaria</i> mycotoxins were calculated, and 100%, 99.2–100%, 0.372% and 1.12% of participants exceeded the threshold of toxicological concern (TTC) values for AOH, AME, TeA and TEN, respectively. This study revealed high potential health risks related to the contaminations of major <i>Alternaria</i> mycotoxins in China and highlighted the necessity for more toxicological studies to provide better basis for further comprehensive risk assessments.
format	article
author	Kai Fan Wenbo Guo Qingwen Huang Jiajia Meng Qi Yao Dongxia Nie Zheng Han Zhihui Zhao
author_facet	Kai Fan Wenbo Guo Qingwen Huang Jiajia Meng Qi Yao Dongxia Nie Zheng Han Zhihui Zhao
author_sort	Kai Fan
title	Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach
title_short	Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach
title_full	Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach
title_fullStr	Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach
title_full_unstemmed	Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach
title_sort	assessment of human exposure to five <i>alternaria</i> mycotoxins in china by biomonitoring approach
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6213e7580c7f45d9a07b548ea1c45ad8
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Assessment of Human Exposure to Five <i>Alternaria</i> Mycotoxins in China by Biomonitoring Approach

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