Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Colibactin-producing pks+ Escherichia coli are frequent constituents of the human intestinal microbiota. Here, the authors show that short exposure of cells to pks+ E. coli induces chromosomal aberrations, genomic instability, and multiple features of transformation reminiscent of colorectal cancer.

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Autores principales:	Amina Iftekhar, Hilmar Berger, Nassim Bouznad, Julian Heuberger, Francesco Boccellato, Ulrich Dobrindt, Heiko Hermeking, Michael Sigal, Thomas F. Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6216b08bac074ebf879284a8ec39ba76
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spelling	oai:doaj.org-article:6216b08bac074ebf879284a8ec39ba762021-12-02T14:11:08ZGenomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells10.1038/s41467-021-21162-y2041-1723https://doaj.org/article/6216b08bac074ebf879284a8ec39ba762021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21162-yhttps://doaj.org/toc/2041-1723Colibactin-producing pks+ Escherichia coli are frequent constituents of the human intestinal microbiota. Here, the authors show that short exposure of cells to pks+ E. coli induces chromosomal aberrations, genomic instability, and multiple features of transformation reminiscent of colorectal cancer.Amina IftekharHilmar BergerNassim BouznadJulian HeubergerFrancesco BoccellatoUlrich DobrindtHeiko HermekingMichael SigalThomas F. MeyerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amina Iftekhar Hilmar Berger Nassim Bouznad Julian Heuberger Francesco Boccellato Ulrich Dobrindt Heiko Hermeking Michael Sigal Thomas F. Meyer Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
description	Colibactin-producing pks+ Escherichia coli are frequent constituents of the human intestinal microbiota. Here, the authors show that short exposure of cells to pks+ E. coli induces chromosomal aberrations, genomic instability, and multiple features of transformation reminiscent of colorectal cancer.
format	article
author	Amina Iftekhar Hilmar Berger Nassim Bouznad Julian Heuberger Francesco Boccellato Ulrich Dobrindt Heiko Hermeking Michael Sigal Thomas F. Meyer
author_facet	Amina Iftekhar Hilmar Berger Nassim Bouznad Julian Heuberger Francesco Boccellato Ulrich Dobrindt Heiko Hermeking Michael Sigal Thomas F. Meyer
author_sort	Amina Iftekhar
title	Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
title_short	Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
title_full	Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
title_fullStr	Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
title_full_unstemmed	Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
title_sort	genomic aberrations after short-term exposure to colibactin-producing e. coli transform primary colon epithelial cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6216b08bac074ebf879284a8ec39ba76
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Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

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