C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

Hexanucleotide GGGGCC repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here the authors show that (GGGGCC) n translation can initiate without a 5′-cap, and this cap-independent translation is upregulated by stress m...

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Autores principales:	Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, Chenglai Fu, Andres Makarem, Fengfan Xian, Lindsey R. Hayes, Rodrigo Lopez-Gonzalez, Kevin Drenner, Jie Jiang, Don W. Cleveland, Shuying Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/621c0d12d9364a1fa8644f3df71f58af
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spelling	oai:doaj.org-article:621c0d12d9364a1fa8644f3df71f58af2021-12-02T14:40:05ZC9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation10.1038/s41467-017-02495-z2041-1723https://doaj.org/article/621c0d12d9364a1fa8644f3df71f58af2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02495-zhttps://doaj.org/toc/2041-1723Hexanucleotide GGGGCC repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here the authors show that (GGGGCC) n translation can initiate without a 5′-cap, and this cap-independent translation is upregulated by stress mediated through eIF2α phosphorylation.Weiwei ChengShaopeng WangAlexander A. MestreChenglai FuAndres MakaremFengfan XianLindsey R. HayesRodrigo Lopez-GonzalezKevin DrennerJie JiangDon W. ClevelandShuying SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiwei Cheng Shaopeng Wang Alexander A. Mestre Chenglai Fu Andres Makarem Fengfan Xian Lindsey R. Hayes Rodrigo Lopez-Gonzalez Kevin Drenner Jie Jiang Don W. Cleveland Shuying Sun C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
description	Hexanucleotide GGGGCC repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here the authors show that (GGGGCC) n translation can initiate without a 5′-cap, and this cap-independent translation is upregulated by stress mediated through eIF2α phosphorylation.
format	article
author	Weiwei Cheng Shaopeng Wang Alexander A. Mestre Chenglai Fu Andres Makarem Fengfan Xian Lindsey R. Hayes Rodrigo Lopez-Gonzalez Kevin Drenner Jie Jiang Don W. Cleveland Shuying Sun
author_facet	Weiwei Cheng Shaopeng Wang Alexander A. Mestre Chenglai Fu Andres Makarem Fengfan Xian Lindsey R. Hayes Rodrigo Lopez-Gonzalez Kevin Drenner Jie Jiang Don W. Cleveland Shuying Sun
author_sort	Weiwei Cheng
title	C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
title_short	C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
title_full	C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
title_fullStr	C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
title_full_unstemmed	C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
title_sort	c9orf72 ggggcc repeat-associated non-aug translation is upregulated by stress through eif2α phosphorylation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/621c0d12d9364a1fa8644f3df71f58af
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C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

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