Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.
<h4>Background</h4>Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-...
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oai:doaj.org-article:621e0408d07e4c2bb8b03e50013ef88d2021-11-18T07:03:28ZVariants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.1932-620310.1371/journal.pone.0013261https://doaj.org/article/621e0408d07e4c2bb8b03e50013ef88d2010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20948998/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied.<h4>Methods and principal findings</h4>Data of two population-based-birth-cohorts in The Netherlands and Germany (KOALA, LISA) were pooled (n = 879) and analyzed by (logistic) regression regarding the mutual influence of single-nucleotide-polymorphisms (SNPs) in the FADS-gene-cluster (rs174545, rs174546, rs174556, rs174561, rs3834458), on polyunsaturated fatty acids (PUFA) in blood and parent-reported eczema until the age of 2 years. All SNPs were highly significantly associated with all PUFAs except for alpha-linolenic-acid and eicosapentaenoic-acid, also after correction for multiple-testing. All tested SNPs showed associations with eczema in the LISA-study, but not in the KOALA-study. None of the PUFAs was significantly associated with eczema neither in the pooled nor in the analyses stratified by study-cohort.<h4>Conclusions and significance</h4>PUFA-composition in young children's blood is under strong control of the FADS-gene-cluster. Inconsistent results were found for a link between these genetic-variants with eczema. PUFA in blood was not associated with eczema. Thus the hypothesis of an inflammatory-link between PUFA and eczema by the metabolic-pathway of LC-PUFAs as precursors for inflammatory prostaglandins and leukotrienes could not be confirmed by these data.Peter RzehakCarel ThijsMarie StandlMonique MommersClaudia GlaserEugène JansenNorman KloppGerard H KoppelmanPaula SingmannDirkje S PostmaStefanie SausenthalerPieter C DagneliePiet A van den BrandtBerthold KoletzkoJoachim HeinrichKOALA study groupLISA study groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13261 (2010) |
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Medicine R Science Q Peter Rzehak Carel Thijs Marie Standl Monique Mommers Claudia Glaser Eugène Jansen Norman Klopp Gerard H Koppelman Paula Singmann Dirkje S Postma Stefanie Sausenthaler Pieter C Dagnelie Piet A van den Brandt Berthold Koletzko Joachim Heinrich KOALA study group LISA study group Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. |
| description |
<h4>Background</h4>Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied.<h4>Methods and principal findings</h4>Data of two population-based-birth-cohorts in The Netherlands and Germany (KOALA, LISA) were pooled (n = 879) and analyzed by (logistic) regression regarding the mutual influence of single-nucleotide-polymorphisms (SNPs) in the FADS-gene-cluster (rs174545, rs174546, rs174556, rs174561, rs3834458), on polyunsaturated fatty acids (PUFA) in blood and parent-reported eczema until the age of 2 years. All SNPs were highly significantly associated with all PUFAs except for alpha-linolenic-acid and eicosapentaenoic-acid, also after correction for multiple-testing. All tested SNPs showed associations with eczema in the LISA-study, but not in the KOALA-study. None of the PUFAs was significantly associated with eczema neither in the pooled nor in the analyses stratified by study-cohort.<h4>Conclusions and significance</h4>PUFA-composition in young children's blood is under strong control of the FADS-gene-cluster. Inconsistent results were found for a link between these genetic-variants with eczema. PUFA in blood was not associated with eczema. Thus the hypothesis of an inflammatory-link between PUFA and eczema by the metabolic-pathway of LC-PUFAs as precursors for inflammatory prostaglandins and leukotrienes could not be confirmed by these data. |
| format |
article |
| author |
Peter Rzehak Carel Thijs Marie Standl Monique Mommers Claudia Glaser Eugène Jansen Norman Klopp Gerard H Koppelman Paula Singmann Dirkje S Postma Stefanie Sausenthaler Pieter C Dagnelie Piet A van den Brandt Berthold Koletzko Joachim Heinrich KOALA study group LISA study group |
| author_facet |
Peter Rzehak Carel Thijs Marie Standl Monique Mommers Claudia Glaser Eugène Jansen Norman Klopp Gerard H Koppelman Paula Singmann Dirkje S Postma Stefanie Sausenthaler Pieter C Dagnelie Piet A van den Brandt Berthold Koletzko Joachim Heinrich KOALA study group LISA study group |
| author_sort |
Peter Rzehak |
| title |
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. |
| title_short |
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. |
| title_full |
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. |
| title_fullStr |
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. |
| title_full_unstemmed |
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. |
| title_sort |
variants of the fads1 fads2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2010 |
| url |
https://doaj.org/article/621e0408d07e4c2bb8b03e50013ef88d |
| work_keys_str_mv |
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