Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.

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Autores principales:	Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor, Peter Friedl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62213730d2074330a309addcd60ee54f
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spelling	oai:doaj.org-article:62213730d2074330a309addcd60ee54f2021-12-02T19:04:19ZCytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity10.1038/s41467-021-25282-32041-1723https://doaj.org/article/62213730d2074330a309addcd60ee54f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25282-3https://doaj.org/toc/2041-1723Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.Bettina WeigelinAnnemieke Th. den BoerEsther WagenaKelly BroenHarry DolstraRob J. de BoerCarl G. FigdorJohannes TextorPeter FriedlNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bettina Weigelin Annemieke Th. den Boer Esther Wagena Kelly Broen Harry Dolstra Rob J. de Boer Carl G. Figdor Johannes Textor Peter Friedl Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
description	Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.
format	article
author	Bettina Weigelin Annemieke Th. den Boer Esther Wagena Kelly Broen Harry Dolstra Rob J. de Boer Carl G. Figdor Johannes Textor Peter Friedl
author_facet	Bettina Weigelin Annemieke Th. den Boer Esther Wagena Kelly Broen Harry Dolstra Rob J. de Boer Carl G. Figdor Johannes Textor Peter Friedl
author_sort	Bettina Weigelin
title	Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
title_short	Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
title_full	Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
title_fullStr	Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
title_full_unstemmed	Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
title_sort	cytotoxic t cells are able to efficiently eliminate cancer cells by additive cytotoxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62213730d2074330a309addcd60ee54f
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Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

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