A review of neuroimaging studies of anxiety disorders in China

Jing Chen, Shenxun ShiDepartment of Psychiatry, Huashan Hospital, Fudan University, Shanghai, ChinaBackground: Anxiety disorders are highly prevalent internationally, and constitute a substantial social and economic burden for patients, their families, and society. A number of neuroimaging studies h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen J, Shi S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6225c802d3b24834ba5915bf11b69226
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6225c802d3b24834ba5915bf11b69226
record_format	dspace
spelling	oai:doaj.org-article:6225c802d3b24834ba5915bf11b692262021-12-02T00:18:55ZA review of neuroimaging studies of anxiety disorders in China1176-63281178-2021https://doaj.org/article/6225c802d3b24834ba5915bf11b692262011-05-01T00:00:00Zhttp://www.dovepress.com/a-review-of-neuroimaging-studies-of-anxiety-disorders-in-china-a7307https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jing Chen, Shenxun ShiDepartment of Psychiatry, Huashan Hospital, Fudan University, Shanghai, ChinaBackground: Anxiety disorders are highly prevalent internationally, and constitute a substantial social and economic burden for patients, their families, and society. A number of neuroimaging studies have investigated the etiology of anxiety disorders in China in the last decade. We discuss the findings of these studies, and compare them with the results of neuroimaging studies of anxiety disorders outside China.Method: A literature search was conducted using the Chinese BioMedical Literature Database, the Chinese Scientific and Technical Periodicals Database, the Chinese Journal Full-text Database, and PubMed, from 1989 to April 2009. We selected neuroimaging studies in which all participants and researchers were Chinese.Results: Twenty-five studies fit our inclusion criteria. Nine studies examined general anxiety disorder (GAD) and/or panic disorder (PD), eight examined obsessive-compulsive disorder (OCD), and eight examined posttraumatic stress disorder (PTSD). Our literature review revealed several general findings. First, reduced regional cerebral blood flow (rCBF) was found in the frontal lobe and temporal lobe in patients with GAD and PD compared with healthy controls. Second, when viewing images with negative and positive valence, relatively increased or decreased activation was found in several brain areas in patients with GAD and PD, respectively. Third, studies with positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) imaging revealed that OCD patients exhibited hyperperfusion and hypoperfusion in some brain regions compared with healthy controls. Neuroimaging studies of PTSD indicate that the hippocampal volume and the N-acetylaspartic acid (NAA) level and the NAA/creatine ratio in the hippocampus are decreased in patients relative to controls.Conclusion: Neuroimaging studies within and outside China have provided evidence of specific neurobiological changes associated with anxiety disorders. However, results have not been entirely consistent across different studies of patients with the same diagnoses. International collaborative research using large samples and robust designs should be conducted in future.Keywords: anxiety disorders, neuroimaging, GAD, PD, OCD, PTSDChen JShi SDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 241-249 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen J Shi S A review of neuroimaging studies of anxiety disorders in China
description	Jing Chen, Shenxun ShiDepartment of Psychiatry, Huashan Hospital, Fudan University, Shanghai, ChinaBackground: Anxiety disorders are highly prevalent internationally, and constitute a substantial social and economic burden for patients, their families, and society. A number of neuroimaging studies have investigated the etiology of anxiety disorders in China in the last decade. We discuss the findings of these studies, and compare them with the results of neuroimaging studies of anxiety disorders outside China.Method: A literature search was conducted using the Chinese BioMedical Literature Database, the Chinese Scientific and Technical Periodicals Database, the Chinese Journal Full-text Database, and PubMed, from 1989 to April 2009. We selected neuroimaging studies in which all participants and researchers were Chinese.Results: Twenty-five studies fit our inclusion criteria. Nine studies examined general anxiety disorder (GAD) and/or panic disorder (PD), eight examined obsessive-compulsive disorder (OCD), and eight examined posttraumatic stress disorder (PTSD). Our literature review revealed several general findings. First, reduced regional cerebral blood flow (rCBF) was found in the frontal lobe and temporal lobe in patients with GAD and PD compared with healthy controls. Second, when viewing images with negative and positive valence, relatively increased or decreased activation was found in several brain areas in patients with GAD and PD, respectively. Third, studies with positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) imaging revealed that OCD patients exhibited hyperperfusion and hypoperfusion in some brain regions compared with healthy controls. Neuroimaging studies of PTSD indicate that the hippocampal volume and the N-acetylaspartic acid (NAA) level and the NAA/creatine ratio in the hippocampus are decreased in patients relative to controls.Conclusion: Neuroimaging studies within and outside China have provided evidence of specific neurobiological changes associated with anxiety disorders. However, results have not been entirely consistent across different studies of patients with the same diagnoses. International collaborative research using large samples and robust designs should be conducted in future.Keywords: anxiety disorders, neuroimaging, GAD, PD, OCD, PTSD
format	article
author	Chen J Shi S
author_facet	Chen J Shi S
author_sort	Chen J
title	A review of neuroimaging studies of anxiety disorders in China
title_short	A review of neuroimaging studies of anxiety disorders in China
title_full	A review of neuroimaging studies of anxiety disorders in China
title_fullStr	A review of neuroimaging studies of anxiety disorders in China
title_full_unstemmed	A review of neuroimaging studies of anxiety disorders in China
title_sort	review of neuroimaging studies of anxiety disorders in china
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/6225c802d3b24834ba5915bf11b69226
work_keys_str_mv	AT chenj areviewofneuroimagingstudiesofanxietydisordersinchina AT shis areviewofneuroimagingstudiesofanxietydisordersinchina AT chenj reviewofneuroimagingstudiesofanxietydisordersinchina AT shis reviewofneuroimagingstudiesofanxietydisordersinchina
_version_	1718403803025244160

A review of neuroimaging studies of anxiety disorders in China

Ejemplares similares